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You look after your sleep, diet and movement, and treat supplements as part of the plan. Butyrate adds to your routine what good bacteria produce in the gut.
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Who it’s for
When is supplementation worth considering?
- You often have a bloated, tight stomach
- You feel discomfort after meals
- You struggle with irregular bowel movements
- You’ve been diagnosed with irritable bowel syndrome (IBS)
Gut · Sodium butyrate · Micropellets4.9· 50 reviews
PURE BUTYRATE™
PURE BUTYRATE™ delivers 960 mg of butyric acid per day, a natural energy source for the cells of the colon.Digestive comfort matters every day: after meals, at work, while traveling and when you’re active. PURE BUTYRATE™ delivers 960 mg of butyric acid per day, a natural energy source for the cells of the colon. Thanks to advanced MicroPelleting™ technology, the sodium butyrate is protected from premature release during digestion, so it reaches the colon, its key site of action.
Everyday gut comfort. At work, on the road and after meals. Butyric acid supports the intestinal lining, and its supplementation is being studied for easing certain digestive complaints.
Natural gut protection. Every day, the gut barrier separates the inside of your body from the contents of your digestive tract. Butyrate is involved in the mechanisms that keep this barrier tight.
Energy for gut cells. Colon cells renew themselves constantly, and butyric acid is one of their main sources of energy.
MicroPelleting™. Micropellets protect the butyrate from being released in the upper digestive tract, so it reaches the colon. As a bonus, butyrate’s unpleasant smell disappears.
30 servings per jar2 capsules daily60 HPMC capsules
€149,97€149,97
You save €0,00€49,99 per jar · €1,66 per day
One-time purchase · Secure online payments
- 30 servings2 capsules per day
- 90 days risk-freeMoney-back guarantee
- MicropelletsSee the technology →
“I'm not a fan of overly complicated supplements, but one specific thing caught my eye: the micro-pellet technology. It's laid out nicely.”
★★★★★Ursula G. · Customer review
“Ingredients: a plus. Transparency: a plus. Most interesting detail: the HPMC capsule. The price deserves some thought, but I like the overall...”
★★★★Alice R. · Customer review
“Without making claims about results, the MicroPelleting™ micro-pellets and the clear, gelatin-free capsule deserve attention. These are verifiable product features.”
★★★★★Joanna W. · Customer review
Shipping: orders processed within 24 hours, delivery cost shown in the cart (shipping policy) · Contact: [email protected]
Food supplements should not be used as a substitute for a varied diet. For adults only. Do not exceed the recommended daily dose. Pregnant and breastfeeding women should consult a doctor before use. This product is a source of sodium, which is worth keeping in mind if you follow a low-salt diet.
Key benefits of PURE BUTYRATE™.
We start with what you may notice day to day: after meals, at work, on the road. Behind every benefit is a specific mechanism in the colon.
01Comfort after meals
In a study of people with irritable bowel syndrome, microencapsulated sodium butyrate reduced the frequency of abdominal pain compared with placebo.4
- Lighter after meals
Potentially less discomfort and abdominal fullness. That’s what preliminary clinical studies in people with IBS suggest.4
- Less time thinking about your gut
Less attention spent on gut complaints at work, on the road and during training.
- No butyrate smell
Regular butyrate smells like rancid butter. Micropellets lock it inside, so the capsule is virtually odorless.
02A better-functioning gut
Five mechanisms through which butyric acid supports normal colon function.
1The energy your gut needs every day
You support the basic processes that normal colon function depends on.
Colon cells work constantly to keep it functioning normally. Butyric acid is one of their main sources of energy, supporting their daily activity and renewal.1
2Natural protection you can rely on
You support your gut’s natural protective mechanisms, which help control your body’s contact with substances in the digestive tract every day.
Your gut isn’t just where digestion happens; it’s also one of your body’s key protective barriers. Butyric acid is involved in maintaining the junctions between intestinal epithelial cells, helping preserve the integrity of this barrier.6
3Continuous renewal for long-term gut health
You support biological processes that matter for keeping your gut in good condition over the long term.
The intestinal epithelium renews itself regularly, replacing worn-out cells with new ones. Butyric acid is involved in regulating the processes responsible for the function, differentiation and renewal of these cells.13
4Immune balance starts in the gut, too
You support mechanisms that help maintain normal immune balance in the gut.
The gut is one of the key sites of immune activity. Butyric acid is involved in regulating the immune response and pathways linked to inflammation.5,9
5The right environment for your microbiota
You support one of the mechanisms that help shape a normal colon environment.
Trillions of microorganisms live in the gut, helping break down food components and produce important metabolites. Butyric acid, used by epithelial cells, helps maintain conditions that favor anaerobic bacteria.
Butyrate is also being studied in the context of the gut–brain axis and glucose metabolism. These are research directions, not promises: supplementation has not been shown to boost energy, reduce post-meal drowsiness, improve focus or lower stress.
03The gut as the foundation of a healthy body
- Energy and everyday performance
Digestion and nutrient absorption give your body energy for work, movement and daily activity.7
- Brain and well-being
The gut communicates with the brain via the nervous, immune and hormonal systems. This interplay is involved in regulating mood and the stress response.8
- Immunity
A large part of the immune system operates in the gut. The gut barrier and microbiota regulate the body’s contact with microbes.9
- Metabolism and glucose
The microbiota and its metabolites take part in signaling related to energy use, glucose, insulin and gut hormones.10
- Longevity and healthy aging
Barrier integrity, microbiota diversity and inflammatory balance are being studied in the context of healthy aging.11
- Fitness and recovery
Good nutrient absorption supplies your muscles with what they need for exertion and repair.12
- Intestinal barrier
The epithelium controls what passes from the gut lumen into the body. Butyric acid is involved in maintaining this barrier.6
- Inflammatory balance
Microbiota metabolites, including butyrate, act on immune cells and inflammatory pathways.5,9
These tiles describe gut physiology based on scientific research. They are not claims about the product’s effects.
References
- Roediger W.E., Gut 1980;21(9):793-798, doi:10.1136/gut.21.9.793 (butyrate as fuel for colonocytes)
- EFSA NDA Panel, EFSA Journal 2010;8(3):1462, doi:10.2903/j.efsa.2010.1462 (dietary reference values for fiber)
- Stephen A.M. et al., Nutr Res Rev 2017;30(2):149-190, doi:10.1017/S095442241700004X (dietary fiber intake)
- Banasiewicz T. et al., Colorectal Dis 2013;15(2):204-209, doi:10.1111/j.1463-1318.2012.03152.x (microencapsulated butyrate in IBS)
- Furusawa Y. et al., Nature 2013;504(7480):446-450, doi:10.1038/nature12721 (butyrate and regulatory T cells in the gut)
- Peng L. et al., J Nutr 2009;139(9):1619-1625, doi:10.3945/jn.109.104638 (butyrate and tight junctions)
- Koh A. et al., Cell 2016;165(6):1332-1345, doi:10.1016/j.cell.2016.05.041 (from dietary fiber to host physiology)
- Cryan J.F. et al., Physiol Rev 2019;99(4):1877-2013, doi:10.1152/physrev.00018.2018 (the microbiota–gut–brain axis)
- Belkaid Y., Hand T.W., Cell 2014;157(1):121-141, doi:10.1016/j.cell.2014.03.011 (microbiota, immunity and inflammation)
- Canfora E.E. et al., Nat Rev Endocrinol 2015;11(10):577-591, doi:10.1038/nrendo.2015.128 (SCFAs, body weight and insulin sensitivity)
- Biagi E. et al., Curr Biol 2016;26(11):1480-1485, doi:10.1016/j.cub.2016.04.016 (microbiota and longevity)
- Clark A., Mach N., J Int Soc Sports Nutr 2016;13:43, doi:10.1186/s12970-016-0155-6 (exercise and the microbiota)
- Hamer H.M. et al., Aliment Pharmacol Ther 2008;27(2):104-119, doi:10.1111/j.1365-2036.2007.03562.x (the role of butyrate in the colon)
Different lifestyles. One goal: a well-functioning gut.
We designed the formula to meet the expectations of the most demanding.
Fast-paced lifestyle
Quick meals, few vegetables, legumes or whole grains. Less fiber means less raw material for bacteria to make butyrate from.
Demanding training
Hard workouts, a tight schedule and a performance-driven diet. Your gut is part of your form too, so you look after it every day, not just your muscles.
Results after 90 days.
From everyday comfort to long-term gut health.
Regular intake of butyric acid supports the basic physiological processes of the colon. See how potential changes in gut comfort could translate into your everyday life. Individual results may vary.
960mg
of butyric acid per daily serving, i.e. 1200 mg of sodium butyrate.
2 capsules once a day, with a meal.
- Day14
First signs of greater comfort.
You may start to notice the first positive changes in how your gut works. Potentially less heaviness, tension and abdominal discomfort after meals can make eating a more enjoyable part of your day.
- Day30
Less bloating, more ease.
You may notice that bloating, fullness and other gut complaints become less bothersome. If you do feel this improvement, everyday life may feel more comfortable.
- Day60
Better gut function, more everyday comfort.
You may experience steadier digestive comfort, while earlier bloating, tension or abdominal pain may be less intense or occur less often. This is a potential stage at which it becomes easier to see how much a well-functioning gut matters for everyday activity.
- Day90
A healthy gut, the foundation of a well-functioning body.
You may notice that greater gut comfort has become part of your daily life. A well-functioning gut is involved in processes that matter for the whole body: metabolism, nutrition, immunity and communication with the brain.
PURE BUTYRATE™ vs regular sodium butyrate.
Sodium butyrate is a cheap raw material. The hard part is something else: delivering it beyond the stomach, in a form you can take every day.
| What matters |  PURE BUTYRATE™ | Regular sodium butyrate |
|---|---|---|
| Sodium butyrate per serving | 1200 mg | Depends on the brand |
| Butyric acid per serving | 960 mg | Depends on the brand |
| Form | Micropellets | Powder or tablet |
| Extended release | Yes | Rarely |
| Rancid butter smell | Virtually none | Intense |
| Plant-based HPMC capsule | Yes | Depends on the brand |
| Fillers and colorings | None | Often |
| Capsules per day | 2, once daily | 3–6 |
1
active ingredientSodium butyrate, nothing else
1200mg
sodium butyratePer daily serving
960mg
butyric acid80% of sodium butyrate by weight
90
days risk-freeTest the routine for yourself
Butyrate that survives digestion.
Regular sodium butyrate has two problems: it is absorbed quickly at the very start of the digestive tract, and it smells like rancid butter. Micropellets solve both. The capsule is transparent, so you can see them with the naked eye.
The micropellet’s journey through the digestive tract.
HPMC capsuleplant-based, dissolves in the stomach
Micropelletsgradually release sodium butyrate
Colonocytes
micropelletreleased butyrateIllustrative diagram, not to scale
Inside the PURE BUTYRATE™ food supplement.
One active ingredient in three layers: the molecule, the pellet and the capsule. Each one has its own job.
1200 mg of sodium butyrate
Daily serving: 2 capsules
No reference intake (RI) has been set for sodium butyrate. The bars show each component’s share of the serving by weight.
1200 mg dailySodium butyrate
The sodium salt of butyric acid, a short-chain fatty acid (SCFA). The main energy source for colonocytes.
600 mg per capsuleMicropellets
Micropelleting Technology™: extended release, stability and no odor.
HPMC shellPlant-based capsule
Shell made of hydroxypropyl methylcellulose. Gelatin-free and suitable for vegans.
Ingredients backed by research.
Expand an item to see how it works.
Sodium butyrate (sodium salt of butanoic acid) · 1200 mg · including 960 mg of butyric acid1200 mg daily
Butyric acid is a fatty acid with four carbon atoms. In the colon, it is produced when bacteria ferment fiber, and it is used on the spot by epithelial cells, which get most of their energy from it. In supplements it is used as a salt, sodium butyrate: 1200 mg of sodium butyrate corresponds to 960 mg of butyric acid. There are no EU-authorized health claims for butyrate.
Mechanism: The sodium salt of butyric acid, a short-chain fatty acid (SCFA). The main energy source for colonocytes.
Butyric (butanoic) acid · 960 mg per daily serving960 mg
Along with acetate and propionate, it is one of the three main short-chain fatty acids in the colon. It is produced by bacteria of genera such as Faecalibacterium, Roseburia and Eubacterium. It acts locally: most butyrate is used up by the epithelium before it reaches the blood.
Mechanism: 80% of sodium butyrate by weight. This is the molecule the intestinal epithelium actually uses.
Why we created PURE BUTYRATE™.
Because with butyrate, the hard part isn’t “what to add” but how to deliver it. Free butyrate is absorbed quickly in the upper digestive tract and smells so strong that it is hard to take every day.
So instead of piling on more extracts, we enclosed the full dose in extended-release micropellets. The capsule is transparent, so you can see what you’re taking.
PURE BUTYRATE isn’t an “everything for your gut” blend. It’s a single molecule at a full dose, in a carefully designed form. Purity, bioavailability and consistency are the SYNTHAGEN standard.
Customer reviews.
Reviews come from our store’s customers. Individual experiences may vary.
100%4- and 5-star ratings
50reviews from customers
90%5-star ratings
Customer review
Most interesting detail: micro-pellet technologyI'm not a fan of overly complicated supplements, but one specific thing caught my eye: the micro-pellet technology. It's laid out nicely.
UG
Ursula G.27.10.2026
Customer review
Good formula, but I'm checking the priceIngredients: a plus. Transparency: a plus. Most interesting detail: the HPMC capsule. The price deserves some thought, but I like the overall formula. The only downside is that the micro-pellet format needs a brief explanation.
AR
Alice R.25.10.2026
Customer review
Specifications, not slogansWithout making claims about results, the MicroPelleting™ micro-pellets and the clear, gelatin-free capsule deserve attention. These are verifiable product features.
JW
Joanna W.23.10.2026
Customer review
Specifics matter when comparing productsCompared with gut-support blends containing multiple extracts, I see an interesting difference here. What stands out most to me is the 960 mg of butyric acid per serving.
CK
Christopher K.22.10.2026
Customer review
In short: good ingredientsPoints for a transparent ingredient list. And points for taking two capsules with a meal.
CN
Cam N.20.10.2026
Customer review
Most interesting detail: micro-pellet technologyI'm not a fan of overly complicated supplements, but one specific thing caught my eye: the micro-pellet technology. It's laid out nicely.
UG
Ursula G.27.10.2026
Customer review
Good formula, but I'm checking the priceIngredients: a plus. Transparency: a plus. Most interesting detail: the HPMC capsule. The price deserves some thought, but I like the overall formula. The only downside is that the micro-pellet format needs a brief explanation.
AR
Alice R.25.10.2026
Customer review
Specifications, not slogansWithout making claims about results, the MicroPelleting™ micro-pellets and the clear, gelatin-free capsule deserve attention. These are verifiable product features.
JW
Joanna W.23.10.2026
Customer review
Specifics matter when comparing productsCompared with gut-support blends containing multiple extracts, I see an interesting difference here. What stands out most to me is the 960 mg of butyric acid per serving.
CK
Christopher K.22.10.2026
Customer review
In short: good ingredientsPoints for a transparent ingredient list. And points for taking two capsules with a meal.
CN
Cam N.20.10.2026
User reviews.
Creators sharing their experiences with Synthagen.
Gracjan Szostak@szostak_gracjan
Marlena Jarmasz@marlenajarmasz
Krystian Kipiel@trenuj_z_krystianem
Wiktoria Różańska@thoria.fitness
Maciej Szot@czajebaze
Paulina@paulina.j_m
Ilona Kwiecińska@kwiecinskailona
Patryk Chmura@rozchmurz_sie
Patryk Chmura@rozchmurz_sieGet started in three steps.
1
Take 2 capsules daily
Once a day, ideally with a meal, with water.
2
Get enough fiber
Vegetables, legumes and whole grains are the raw material your bacteria use to make butyrate themselves.
3
Assess after 90 days
30 servings per jar. Three jars cover 90 days of regular use.
90DAYS RISK-FREE
Try it risk-free.
90-day money-back guarantee. Take PURE BUTYRATE™ regularly and see how it fits your routine. If it’s not for you, you’re covered by our money-back guarantee. Return policy.
Add to cartFrequently asked questions.
Didn’t find the answer to your question? Write to us: [email protected]
Buy PURE BUTYRATEHow do I take PURE BUTYRATE™?
2 capsules once a day, ideally with a meal, with water. Do not exceed the recommended daily dose. One jar contains 60 capsules, i.e. 30 servings for one month of use.
Does sodium butyrate have an unpleasant smell?
Not in this form. Regular sodium butyrate gives off a rancid-butter smell when it comes into contact with moisture. In PURE BUTYRATE™ it is enclosed in micropellets, so the capsules are virtually odorless and tasteless.
What is butyric acid, and where does it come from in the body?
It is a short-chain fatty acid that gut bacteria produce from fiber. It is the main energy source for the epithelial cells of the colon. A low-fiber diet means less raw material for producing it.
Can I combine PURE BUTYRATE™ with a probiotic?
Yes, it’s a natural pairing. A probiotic and fiber (e.g. in GUT BALANCE™) support the bacteria that make butyrate themselves, while PURE BUTYRATE™ supplies it directly. The products can be taken at the same time.
What does “extended release” mean?
The butyrate is enclosed in micropellets that release it gradually as they pass through the digestive tract. Free butyrate is absorbed quickly in the upper section, while the pellets ensure that part of the dose is released further along. More in the Technology section.
Is the product suitable for vegans?
Yes. The capsule is made of plant-based hydroxypropyl methylcellulose (HPMC), and the product is GMO-free.
Does the product contain sodium?
Yes, sodium butyrate is the sodium salt of butyric acid. If your doctor has recommended a low-salt diet, consult them before using this product. The daily serving (2 capsules) contains 0.24 g of salt.
How should I store the product, and who is it not intended for?
Store in a tightly closed container in a cool, dry place, away from heat and light, out of reach of children. For adults only. Do not use if you are hypersensitive to any of the ingredients. Pregnant and breastfeeding women should consult a doctor before use.
Three routes to one tissue.
The intestinal lining is a single layer of cells that renews itself every few days, and it needs energy to do so. Two products supply butyrate, its main fuel: one through bacteria, the other ready-made. The third is a peptide that has been studied for more than 30 years in relation to the gastrointestinal mucosa.
1PURE BUTYRATE™
1200 mg sodium butyratein micropellets
Releasegradual, from the pellet in the intestine
butyrate2GUT BALANCE™
FOS and fiberfrom the formula and your diet
Fermentationincl. C. butyricum in the colon
butyrate3NL-BPC-157™
BPC-157 analog16 amino acids, NL-PEPTIDES™
Enteric coatingpasses through the stomach, opens in the intestine
peptideIntestinal liningButyrate: colonocytes burn it in their mitochondria. In Roediger’s study it covered approx. 70% of their energy needs.BPC-157: studied in animal models in relation to the gastric and intestinal mucosa.
PURE BUTYRATE™ + GUT BALANCE™
PURE BUTYRATE™ + GUT BALANCE™ + NL-BPC-157™
€99,98€156,97
Sources: Roediger W.E., Gut 1980;21(9):793-798 (butyrate as an energy source for colonocytes). Stoeva M. et al., Gut Microbes 2021 (C. butyricum produces butyrate). Sikiric P. et al., J Physiol Paris 1993;87(5):313-327 (first description of BPC-157). Sikiric P. et al., Curr Pharm Des 2011;17(16):1612-1632 (BPC-157 in gastrointestinal research). Research on BPC-157 is mainly in animal and cell models. The products have not been shown to treat any disease. Food supplements are not a substitute for a varied diet. If you take medication or have a chronic condition, consult your doctor before use.
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