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Who is NL-BPC-157 made for?
- You deal with stomach and gut complaints
- You feel discomfort in your tendons and joints related to micro-injuries
- You’re regaining mobility after a physical injury
- You want more efficient recovery so you can keep training consistently
Peptides · Recovery · NL-DELIVERY™4.87· 38 reviews
NL-BPC-157™
An N-acetylated and amidated analog of the BPC-157 peptide, encased in an NL-DELIVERY™ double capsule.An N-acetylated and amidated analog of the BPC-157 peptide, encased in an NL-DELIVERY™ double capsule. BPC-157 is a fragment of a protein found in human gastric juice and has been studied for over 30 years in relation to tissue repair processes.
Proprietary NL-PEPTIDES™ technology. A special modification of the peptide’s ends that helps protect it from breakdown by enzymes.
Proprietary NL-DELIVERY™ technology. A “capsule-in-capsule” design that helps protect the peptide from stomach acid and other digestive processes.
200 µg of active ingredient per capsule. The formula was developed to limit degradation of the active ingredient and deliver it in unchanged form.
Two international patents. Every batch tested in laboratories in Poland, Germany and Switzerland.
30 capsules1 capsule daily30 days of use
€165,49€170,97
You save €5,48€55,16 per jar · €1,83 per day
One-time purchase · Secure online payments
- 30 days1 capsule daily
- 90 days risk-freeMoney-back guarantee
- Capsule-in-capsuleSee the technology →
“Good morning. I have been using this product for a long time. When I found this company and tried their product, I...”
★★★★★Dariusz · Verified purchase
“Great product.”
★★★★★Anonymous · Verified purchase
“Helps with my joint pain, and make my guts feel better.”
★★★★★Anonymous · Verified purchase
Shipping: orders processed within 24 hours, delivery cost shown in the cart (shipping policy) · Contact: [email protected]
Food supplements should not be used as a substitute for a varied diet. For adults only. Do not exceed the recommended daily dose. Do not use during pregnancy or breastfeeding. People taking medication or living with a chronic condition should consult a doctor before use.
What does research on BPC-157 focus on?
BPC-157 is one of the best-described peptides in preclinical research. We show what it has been studied for, and we’re honest about what isn’t known yet.
01Muscles, tendons and ligaments
In animal models of ligament and muscle–tendon junction injuries, researchers observed improvements in the organization of healing tissue, its mechanical properties and motor function.
- Cells that rebuild tendons
In laboratory studies on rat tendon cells, researchers observed increased migration of fibroblasts, the cells that produce the components of connective tissue. These cells also showed greater survival under oxidative stress.
- Tissue blood supply
In cell and animal studies, BPC-157 influenced pathways linked to the formation of blood vessels. In a rat model of muscle ischemia, improved blood flow was observed.
- Returning to function
More efficient healing after injury, restored strength in damaged structures and improved motor function. These are directions of preclinical research, not confirmed benefits of using NL-BPC-157 in humans.
Results of BPC-157 research cannot automatically be applied to its modified analog or to a finished oral product.
02Digestive system
Stomach: four directions of preclinical research on protecting the mucosa and how it repairs.
1Protecting the mucosa from damage
Why this direction matters: the potential to limit initial tissue damage and preserve a larger area of normally functioning mucosa. This is a preclinical observation, not proof that the stomach is protected during medication use in humans.
One line of research examines whether BPC-157 can limit the extent of mucosal damage after exposure to a damaging agent. Studies in rats analyzed, among other things, stomach damage caused by indomethacin, a non-steroidal anti-inflammatory drug (NSAID), as well as experimental ulcer models. Under some of the tested conditions, a smaller area of lesions was observed after BPC-157 administration than in the control groups.
2Rebuilding the epithelium and healing existing damage
Why this direction matters: assessing whether the peptide can influence the actual rebuilding of damaged mucosa. Such studies measure changes in tissue, which is not the same as confirming relief from pain, burning or nausea in humans.
Protecting the mucosa also includes its ability to repair itself. Once damage occurs, cells must rebuild the epithelial surface, and the deeper tissues must form a base that allows healing. In a rat model of chronic ulcer, BPC-157 administration was followed by a smaller ulcer area, rebuilding of the glandular epithelium and formation of granulation tissue, a tissue involved in healing.
3Blood supply as a condition for recovery
Why this direction matters: testing whether improved vascular conditions can support cell survival and the rebuilding of damaged tissue. The exact mechanism of action of BPC-157 is still being investigated.
Mucosal repair requires a supply of oxygen and nutrients. That’s why researchers also analyze the effect of BPC-157 on vascular mechanisms and angiogenesis, the formation of new blood vessels. In a rat model of ulcer recurrence associated with clopidogrel administration, changes were observed in markers related to blood vessel formation and the nitric oxide system. The results suggested that these processes play a role in the protective effect observed.
4Inflammatory response and cell survival
Why this direction matters: the potential to limit secondary damage to the mucosa and preserve the cells needed to rebuild it. The results do not establish BPC-157 as a treatment for gastritis in humans.
Inflammation is part of the body’s response to injury. However, excessive or persistent inflammation can accompany further tissue damage. In the same animal model of stomach injury, BPC-157 administration was followed by reduced infiltration of inflammatory cells and lower markers of cellular stress and apoptosis, or programmed cell death.
The results described come from animal studies on BPC-157. They do not confirm the efficacy or safety of the finished NL-BPC-157 product in humans. The modified analog, the oral form and the encapsulation technology require their own data.
03What is BPC-157?
- A peptide made of 15 amino acids
BPC-157 is a small molecule made in the laboratory. It belongs to the peptides, which are short chains of amino acids. Think of amino acids as small building blocks that also make up the proteins in our bodies. BPC-157 consists of 15 such blocks.
- Body Protection Compound
The abbreviation BPC stands for Body Protection Compound. It’s a name given by researchers, and in itself it does not mean the substance has a confirmed protective effect in humans.1
- It all started with the stomach
In the early 1990s, scientists at the University of Zagreb in Croatia were studying substances found in human gastric juice. They wanted to understand how the body protects its tissues from damage. As part of this research, they described a material named BPC, followed by a short fragment designated BPC-157. Publications from 1993–1994 describe this early stage of research.1
- Why did it interest scientists?
In the first experiments in rats, less damage to the stomach and duodenum was observed after BPC-157 administration. This raised a question: could the substance influence the processes by which tissues protect and rebuild themselves? Over time, research expanded to other areas, including muscles, tendons and ligaments.2
- What are scientists trying to understand?
Tissue repair requires many elements to work together. Cells must reach the site of damage, receive oxygen and nutrients, and then rebuild the structures needed. Research on BPC-157 examines whether it influences some of these processes: cell migration, blood vessel formation and the course of healing. Its exact mode of action is still not fully understood.2,3
- BPC-157 sequence, 15 amino acids
GEPPPGKPADDAGLV. In the NL-PEPTIDES™ analog, the chain is longer and its ends are acetylated (N) and amidated (C).
Research concerns BPC-157, not this analog, and is mostly preclinical.
References
- Sikiric P. et al., J Physiol Paris 1993;87(5):313-327 (first description of BPC-157)
- Gwyer D. et al., Cell Tissue Res 2019;377(2):153-159, doi:10.1007/s00441-019-03016-8 (review: BPC-157 and soft tissues)
- Seiwerth S. et al., Curr Pharm Des 2018;24(18):1972-1989, doi:10.2174/1381612824666180712110447 (BPC-157 and angiogenic factors)
Different lifestyles. One goal: more efficient recovery.
A peptide in a capsule, not a syringe. The entire NL-DELIVERY™ technology exists so that the peptide survives its journey through the digestive tract. We designed the formula to meet the expectations of the most demanding.
Fast-paced lifestyle
Stress, irregular meals, coffee on an empty stomach. For people who want to look after the engine of their everyday performance: the gut.
Demanding training
Tendons and ligaments under constant load. For people who train regularly and want to take a deliberate approach to recovery.
Results after 90 days.
How should you plan your course?
One jar holds 30 capsules, or 30 days. Connective tissue, such as tendons and ligaments, remodels slowly, over weeks and months. That’s why consistency matters. Individual results may vary.
1caps.
per day, in the morning on an empty stomach or about 30 minutes before a meal.
This gives the enteric coating the best conditions to work.
- Day14
You notice the first differences.
Stomach discomfort pulls your attention away from daily activities less often. You sit down to meals more calmly and are less often forced to stop what you’re doing because of discomfort. Everyday movement feels more comfortable. A walk, the stairs or prescribed rehabilitation exercises are less of a struggle.
- Day30
Discomfort affects your day less.
You change plans because of stomach discomfort less often. You can focus more on a meeting, work or rest instead of constantly paying attention to discomfort. You go about daily activities with more ease. It’s easier to keep up with your prescribed exercises, and injury-related limitations take up less of your attention.
- Day60
You regain more freedom.
Stomach discomfort sets the rhythm of your day less often. You skip shared meals or planned activities because of discomfort less often. You see progress in activities that used to be difficult. It’s easier to reach your next rehabilitation goals, and you increase your activity level as advised by a specialist.
- Day90
Greater comfort makes a difference in your life.
You spend less time and attention on discomfort. It’s easier to plan your day and, more often, to live it the way you want. You handle daily tasks more easily and return to activities suited to your stage of healing. You regain more independence and more room for the things that matter to you.
NL-BPC-157™ vs regular BPC-157 capsules.
A peptide in a regular capsule has to survive stomach acid and digestive enzymes. The difference isn’t the name on the label, but what happens to the peptide after you swallow it.
| What matters |  NL-BPC-157™ | Regular BPC-157 capsules |
|---|---|---|
| Acetylated and amidated analog | NL-PEPTIDES™ | Rarely |
| Enteric coating | Yes | Depends on the brand |
| Capsule-in-capsule | NL-DELIVERY™ | — |
| Micropellets with pH regulator | Yes | — |
| Technology patents | 2 international | — |
| Batch testing | PL · DE · CH | Depends on the brand |
| Capsules per day | 1 | 1–2 |
2
international patentsNL-PEPTIDES™ · NL-DELIVERY™
3
testing countriesPoland, Germany, Switzerland
16
amino acidsAnalog BPC-157
1
capsule daily30 days per jar
Peptides that digestion won’t dissolve or degrade.
Stomach acid and enzymes break down most peptides before they can be absorbed. That’s why we protect NL-BPC-157™ on three levels.
The peptide’s journey through the digestive tract.
Enteric coatingprotects the peptide in the stomach
Micropelletsrelease the peptide in the intestine
Bloodthe peptide passes into the bloodstream
micropelletreleased peptideIllustrative diagram, not to scale
What’s inside the NL-BPC-157™ food supplement.
One active peptide in three layers of protection: the molecule, the micropellet and the double capsule.
200 µg of active ingredient per capsule
Daily serving: 1 capsule
1 capsuleHexadecapeptide
An N-acetylated and amidated 16-amino-acid analog of BPC-157, developed with NL-PEPTIDES™ technology.
per capsuleMicropellets
An absorption enhancer and an agent that lowers local pH in the intestine. Part of NL-DELIVERY™.
NL-DELIVERY™Double capsule
A capsule-in-capsule with an enteric coating that dissolves only in the intestine.
Ingredients backed by research.
Expand an item to see how it works.
NL-BPC-157™ hexadecapeptide · BPC-157 analog · NL-PEPTIDES™ technology1 capsule
BPC-157 (Body Protection Compound) is a pentadecapeptide, a fragment of a protein found in human gastric juice, first described in 1993. In NL-BPC-157™, the chain is extended to 16 amino acids and both of its ends are capped: the N-terminus by acetylation and the C-terminus by amidation. These are classic modifications in peptide chemistry that make it harder for exopeptidases to cleave the chain. Research concerns BPC-157, not this analog, and is mostly preclinical.
Mechanism: An N-acetylated and amidated 16-amino-acid analog of BPC-157, developed with NL-PEPTIDES™ technology.
BPC-157 mechanism · VEGFR2 receptorVEGFR2
In cell and animal models, BPC-157 increased the expression and activation of the VEGFR2 receptor in endothelial cells, which was associated with faster blood vessel formation. For tissues with a poor blood supply, such as tendons, this is one of the key stages of repair.
Mechanism: The most frequently described mechanism of BPC-157: the formation of new blood vessels.
Why NL-BPC-157™?
Because the biggest problem with oral peptides isn’t the molecule itself, but the path it has to travel. Stomach acid, pepsin and intestinal enzymes break down most peptides before they can be absorbed.
So we protected the peptide on three levels: we modified the molecule itself, encased it in a capsule-in-capsule and added micropellets that prepare the absorption site.
NL-BPC-157 is not “BPC-157 in a capsule.” It’s a molecule and its delivery system, protected by two patents. Purity, bioavailability and consistency are the SYNTHAGEN standard.
Customer reviews.
Reviews come from our store’s customers. Individual experiences may vary.
95%4- and 5-star ratings
38reviews from customers
92%5-star ratings
Verified purchase
Good morning. I have been using this product for a long time. When I found this company and tried their product, I was very satisfied. It is easy and convenient to use. I highly recommend it!
D
Dariusz30.10.2026
Verified purchase
Great product.
A
Anonymous27.10.2026
Verified purchase
Helps with my joint pain, and make my guts feel better.
A
Anonymous05.10.2026
Verified purchase
excellent
A
Anonymous26.08.2026
Customer review
okProduct as described. Fast delivery.
EW
Ewa W.30.07.2026
Verified purchase
habe 4 Monate lang NL-BPC-157 eingenommen, meine Gliederschmerzen hatten sich deutlich verbessert. Mein Stuhlgang normalisiert sich. Machte nun Pause mit der Einnahme und die Gliederschmerzen wurden wieder stärker.
A
Anonymous14.10.2026
Verified purchase
Produit utile
CG
carlo g.11.10.2026
Verified purchase
Hatte einen Fahrradunfall während ich das 1. Mal eine Packung genommen habe. Ich , meine Gelenke und Haut erholten sich sehr schnell. Meine Diskushernie macht weniger Probleme, was ich auf die Einnahme von BPC zurück
M
Maggie20.09.2026
User reviews.
Creators sharing their experiences with Synthagen.
Gracjan Szostak@szostak_gracjan
Marlena Jarmasz@marlenajarmasz
Krystian Kipiel@trenuj_z_krystianem
Wiktoria Różańska@thoria.fitness
Maciej Szot@czajebaze
Paulina@paulina.j_m
Ilona Kwiecińska@kwiecinskailona
Patryk Chmura@rozchmurz_sie
Patryk Chmura@rozchmurz_sieGet started in three steps.
1
Consult a professional if needed
If you have an injury or a chronic condition, or take medication, start with a conversation with your doctor or physiotherapist.
2
1 capsule in the morning
On an empty stomach or about 30 minutes before a meal, with water.
3
Plan for 90 days
30 capsules per jar. A 3-jar set covers the full 90 days at the best price.
90DAYS RISK-FREE
Try it risk-free.
90-day money-back guarantee. Take NL-BPC-157™ regularly and see how it fits your routine. If it’s not for you, the money-back guarantee has you covered. Return policy.
Add to cartFrequently asked questions.
Didn’t find the answer to your question? Write to us: [email protected]
Buy NL-BPC-157How do I take NL-BPC-157™?
1 capsule daily, ideally in the morning on an empty stomach or about 30 minutes before a meal, with water. Do not exceed the recommended serving. A jar contains 30 capsules, or 30 days of use.
How is NL-BPC-157™ different from regular BPC-157?
It’s an extended 16-amino-acid analog of BPC-157, acetylated at the N-terminus and amidated at the C-terminus (NL-PEPTIDES™ technology). These modifications make it harder for enzymes to cleave the peptide. On top of that comes a double capsule with an enteric coating and micropellets (NL-DELIVERY™). Learn more in the Technology section.
Can I use the product long-term?
We recommend planning use in cycles, e.g. 90 days. There are no long-term human studies on BPC-157, so for longer use it’s worth consulting your doctor.
Is the product suitable for both women and men?
Yes, the product is intended for adult women and men. Do not use it during pregnancy or breastfeeding.
Are there any side effects?
No large human safety studies have been conducted on BPC-157. If you take medication, have a chronic condition or a history of cancer, consult your doctor before use. Stop using the product if you notice any worrying symptoms.
Can I combine NL-BPC-157™ with other peptides and supplements?
The product can be used together with vitamins and most food supplements. If you combine several peptides or take medication, consult your doctor before use.
How should I store the product?
At room temperature, in a dry place, in the tightly closed original packaging, away from light and heat, and out of reach of children.
Stomach and gut. Three pathways.
The stomach and gut are the foundation of everyday well-being and a source of vital energy for every one of us. NL-BPC-157™ is a peptide studied in relation to the gastrointestinal mucosa, GUT BALANCE™ provides bacterial cultures and food for them, and PURE BUTYRATE™ provides ready-made butyrate, the main fuel for colon cells.
1NL-BPC-157™
BPC-157 analogin an NL-DELIVERY™ capsule
Mucosal liningstudied in animal models
peptide2GUT BALANCE™
8 strains and FOSapprox. 289 billion CFU
Fermentationincl. C. butyricum in the colon
probiotic3PURE BUTYRATE™
1200 mg sodium butyratein micropellets
Releasegradual, from the pellet in the intestine
butyrateStomach and gutBPC-157: studied in animal models in relation to the stomach and intestinal mucosa.Butyrate: colonocytes burn it in their mitochondria. In Roediger’s study, it covered approx. 70% of their energy needs.Cultures and FOS: a food source and bacteria that produce butyrate in the colon.
NL-BPC-157™ + GUT BALANCE™
NL-BPC-157™ + GUT BALANCE™ + PURE BUTYRATE™
€106,98€156,97
Sources: Roediger W.E., Gut 1980;21(9):793-798 (butyrate as an energy source for colonocytes). Stoeva M. et al., Gut Microbes 2021 (C. butyricum produces butyrate). Sikiric P. et al., J Physiol Paris 1993;87(5):313-327 (first description of BPC-157). Sikiric P. et al., Curr Pharm Des 2011;17(16):1612-1632 (BPC-157 in gastrointestinal research). Research on BPC-157 consists mainly of animal and cell models. There are no EU-authorized health claims for BPC-157, bacterial cultures or butyrate. The products have not been shown to treat any disease. Food supplements are not a substitute for a varied diet. If you take medication or have a chronic condition, consult your doctor before use.
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