English
Clinical study
PURE OXILLIGENCE™
PURE OXILLIGENCE™Resveratrol
Daily serving 300 mg
In the study 150 mg
2× the study dose
Clinical study in men with obesity, 30 days.
Timmers S. et al., Cell Metab 2011
4.9400+reviews90days to return
Don’t just take our word for it.
Got doubts? Good. We’ve gathered the 6 questions that most often hold people back from buying, and we answer each one with numbers you can check.
NOVA CELLCARE™Your doubts.
Our numbers.
Pick whatever is holding you back. Each answer takes less than a minute to read, and below it is a link to the full data further down the page.
An ordinary supplement is powder in a capsule. With us, every ingredient has its own technology.
2
See how each form works ↓
international patent applications for NL-DELIVERY™ and NL-PEPTIDES™. Not something you can buy from a raw-materials wholesaler.
We take the dose from the study and put it next to our daily serving.
study or typical productSynthagen daily serving
2×ResveratrolPURE OXILLIGENCE™150 → 300 mg
1.7×Hyaluronic acidNOVA CELLCARE™120 → 200 mg
1:1AstaxanthinPURE OXILLIGENCE™8 → 8 mg
64×Probiotic bacteriaGUT BALANCE™ vs pharmacy4.5 → 289 billion CFU
Timmers S. et al., Cell Metab 2011 · Oe M. et al., Clin Cosmet Investig Dermatol 2017 · Park J.S. et al., Nutr Metab 2010. A higher dose doesn’t mean a stronger effect. We show it to make clear it isn’t merely symbolic.
All doses with citations ↓You pay more per day. For what you actually swallow, often less.
Typical pharmacy probiotic
- Bacteria per serving
- 4.5billion CFU
- Price per day
- 0.24€
- Per 1 billion bacteria
- 0.05€
GUT BALANCE™
- Bacteria per serving
- 289billion CFU
- Price per day
- 1.67€
- Per 1 billion bacteria
- 0.006€
For every billion bacteria, you pay 9× less. Per day, it costs less than a coffee out.
Typical probiotic: 9 strains, 4.5 billion CFU per capsule, about €12 for 50 capsules (approximate online pharmacy prices). GUT BALANCE™: €49,99 for 30 days.
See GUT BALANCE™ →You don’t have to take our word for it. Independent laboratories in three countries check it.
PLPolandproduction and testing
DEGermanyindependent testing
CHSwitzerlandindependent testing
- A citation with the author’s name next to each dose
- Doses taken from research
- Technology from our own laboratory
- Made in the EU
- Purity, stability and safety testing
Then we refund your money. The risk is ours.
90days to decide
- Take the formula every day for a full cycle. Your body needs time, which is why we give you this much of it.
- Not feeling a difference? Email us at [email protected].
- Get your money back. Even for an opened package.
Details in our refund policy. Most stores only accept returns of unopened products.
Choose a formula to try for 90 days ↓A Polish company based in Krakow with its own laboratory.
CompanyAXIOM ONE sp. z o.o.
LaboratoryOur own. This is where our ingredient delivery technologies are developed.
Contact[email protected]
What matters is what gets through.
On the label, every supplement looks good. The difference is on the inside: the form of the ingredient, the dose, and the research behind them.
Will the ingredient survive the journey?
Five forms matched to the ingredient, from micropellets to a double capsule.Does the dose match the study?
The daily serving next to the study dose, ingredient by ingredient.What’s it based on?
The level of evidence and a citation with the author’s name for every ingredient.Every ingredient has its own form.
In the wrong form, the same ingredient can break down in the stomach or fail to dissolve at all. That’s why bacteria, butyrate, oil, quercetin and peptides each get their own technology.
Micropellets
Sodium butyrate is enclosed in tiny pellets that release it gradually, including further along the gut.
Typical
Powdered butyrate: a pungent smell and immediate release, before it can travel further along the gut.
Ours
Odorless micropellets that release butyrate gradually, including further along the gut.
PURE BUTYRATE™ Microcapsules
Each of the 8 bacterial strains has its own coating that protects it from stomach acid and moisture. Alongside them is the prebiotic FOS.
Typical
Strains without a separate coating, sensitive to acid and moisture, often needing refrigeration.
Ours
Each of the 8 strains in its own microcapsule. No refrigeration needed.
GUT BALANCE™ Oil & pellets
Oil with omega-3 and vitamins D3 and K2, alongside pellets containing five solid ingredients. All in one sealed capsule.
Typical
Oil and solid ingredients in separate capsules, which means several jars instead of one.
Ours
Oil with D3 and K2 plus pellets in one sealed capsule. D3 and K2 are fat-soluble, so they go in the oil.
VITAL OMEGA PRO™ Phytosome
Quercetin bound to phospholipids. Raw quercetin barely dissolves in water, while the phytosome form dissolves better.
Typical
Raw quercetin, which barely dissolves in water.
Ours
Phytosomal quercetin. In a pharmacokinetic study, it produced many times higher blood levels than regular quercetin (Riva A. et al., 2019).
PURE OXILLIGENCE™ Double capsule
Peptides are short chains of amino acids that break down easily in the acidic stomach. That’s why the NL peptide is enclosed in two capsules: the outer one has an enteric coating, and the inner one contains micropellets that prepare the absorption site.
Typical
A peptide in a standard capsule, exposed to stomach acid, in which it breaks down easily.
Ours
The NL-DELIVERY™ double capsule with an enteric coating and micropellets. Two international patent applications.
NL-BPC-157™ and 6 other peptides The animation is an illustrative diagram, not to scale. The descriptions refer to the form of the ingredients and are not claims about the effects of the products.
Dosed by research, not by marketing.
Even the right form of an ingredient does nothing in a token amount. We compare each daily serving with the dose used in research, including where the upper safety limit is what counts.
ResveratrolPURE OXILLIGENCE™
2× the study doseClinical study in men with obesity, 30 daysTimmers S. et al., Cell Metab 2011
AstaxanthinPURE OXILLIGENCE™
Same dose as in the studyClinical study in young women, 8 weeks, doses of 2 and 8 mgPark J.S. et al., Nutr Metab 2010
Hyaluronic acidNOVA CELLCARE™
1.7× the study dosePlacebo-controlled study, 12 weeksOe M. et al., Clin Cosmet Investig Dermatol 2017
EPA + DHAVITAL OMEGA PRO™
2× the claim thresholdCondition for the EU claim on heart functionRegulation (EU) No 432/2012
EGCG from green teaPURE OXILLIGENCE™
40× below the limitEFSA flags safety concerns at this dose and aboveEFSA ANS Panel, EFSA Journal 2018
A higher dose than in the study doesn’t mean a stronger effect. We show it to make clear the dose isn’t merely symbolic.
Not “studies prove.” Specific studies.
For every ingredient, we cite a specific study: author, year and journal. And we tell you plainly how strong that evidence is. Choose a product.
- Strong evidencehuman studies, meta-analyses or an EU-authorized claim
- Moderateobservational data in humans and expert guidelines
- Preliminarylab and animal studies, reviews. A direction, not proof
- Safetylimits and interactions worth knowing
Strong evidence · meta-analysis of multiple studies
Grape seed100 mg
Meta-analysis of randomized trials of grape seed extract and cardiovascular risk markers, including blood pressure.
Feringa et al. (2011), J Am Diet Assoc 111(8):1173-1181Strong evidence · human clinical study
N-acetylcysteine400 mg
In older adults with glutathione deficiency, 14 days of supplementation with cysteine (given as NAC) and glycine restored glutathione synthesis and levels to those of younger people.
Sekhar et al. (2011), Am J Clin Nutr 94(3):847-853+1 more footnote
- Human clinical study
In a pilot clinical trial in older adults, 24 weeks of glycine and NAC supplementation (GlyNAC) improved glutathione levels and markers of oxidative stress, among other outcomes.
Kumar et al. (2021), Clin Transl Med 11(3):e372
Strong evidence · human clinical study
Resveratrol300 mg
In men with obesity, 30 days of 150 mg resveratrol per day changed selected parameters of energy metabolism, including AMPK and SIRT1 activation in muscle.
Timmers et al. (2011), Cell Metab 14(5):612-622+1 more footnote
- Laboratory study
The study that sparked interest in resveratrol: sirtuin activation and extended lifespan in yeast under laboratory conditions.
Howitz et al. (2003), Nature 425:191-196
Strong evidence · human clinical study
Phytosome quercetin200 mg
In healthy volunteers, quercetin in a phytosome form with lecithin produced plasma levels up to about 20 times higher than the same dose of regular quercetin.
Riva et al. (2019), Eur J Drug Metab Pharmacokinet 44(2):169-177+1 more footnote
- Laboratory study
Quercetin was one of the first compounds studied as a senolytic, in combination with dasatinib, in laboratory models.
Zhu et al. (2015), Aging Cell 14(4):644-658
Strong evidence · human clinical study
Astaxanthin8 mg
In young women, 8 weeks of 2 or 8 mg astaxanthin per day lowered a marker of oxidative DNA damage and the acute-phase protein CRP.
Park et al. (2010), Nutr Metab 7:18Preliminary evidence · research review
Turmeric50 mg
A review of research on curcumin and its relevance to human health, including the limits of its bioavailability.
Hewlings, Kalman (2017), Foods 6(10):92Safety · limits and interactions
Grapefruit100 mg
A review of grapefruit–drug interactions, explaining why people taking medication should consult a doctor or pharmacist.
Bailey et al. (2013), CMAJ 185(4):309-316Safety · limits and interactions
Green tea50 mg
EFSA’s safety assessment of green tea catechins: concerns at intakes of 800 mg EGCG per day or more from food supplements.
EFSA ANS Panel (2018), EFSA Journal 16(4):5239Strong evidence · EU-authorized claim
Fish oil EPA + DHA700 mg
EPA and DHA contribute to the normal function of the heart (with a daily intake of 250 mg).
Commission Regulation (EU) No 432/2012+2 more footnotes
- Research review
A review of the role of DHA in cell membranes, the brain and the retina.
Calder P.C. (2016), Ann Nutr Metab 69(Suppl 1):7-21 - Research review
The omega-3 index, i.e. the share of EPA and DHA in red blood cell membranes, as a marker of omega-3 status.
Harris W.S., von Schacky C. (2004), Prev Med 39(1):212-220
Strong evidence · EU-authorized claim
D3 + K2 MK-74000 IU + 100 µg
Vitamins D and K contribute to the maintenance of normal bones. Vitamin D contributes to the maintenance of normal muscle function and to the normal function of the immune system.
Commission Regulation (EU) No 432/2012+2 more footnotes
- Expert guidelines
Polish guidelines: vitamin D supplementation is recommended for most adults, at least from October to March.
Pludowski P. et al. (2023), Nutrients 15(3):695 - Research review
A review of the causes and consequences of vitamin D deficiency.
Holick M.F. (2007), N Engl J Med 357(3):266-281
Strong evidence · EU-authorized claim
Vitamin K2 MK-7100 µg
Vitamin K contributes to the maintenance of normal bones.
Commission Regulation (EU) No 432/2012+2 more footnotes
- Human clinical study
MK-7 has a half-life of about 3 days and provides more stable blood levels than vitamin K1.
Schurgers L.J. et al. (2007), Blood 109(8):3279-3283 - Human clinical study
In postmenopausal women, 3 years of MK-7 intake was studied for bone density and bone strength.
Knapen M.H. et al. (2013), Osteoporos Int 24(9):2499-2507
Strong evidence · EU-authorized claim
Vitamin C200 mg
Vitamin C contributes to normal collagen formation for the normal function of cartilage.
Commission Regulation (EU) No 432/2012+1 more footnote
- Research review
Review: the role of vitamin C in collagen synthesis.
Peterkofsky B. (1991), Am J Clin Nutr 54(6 Suppl):1135S-1140S
Strong evidence · meta-analysis of multiple studies
GingerDER 4:1
Meta-analysis of randomized trials of ginger in people with knee and hip joint complaints.
Bartels E.M. et al. (2015), Osteoarthritis Cartilage 23(1):13-21Strong evidence · human clinical study
Type II collagen (UC-II)80 mg
In a 180-day randomized, placebo-controlled study, undenatured type II collagen was assessed for knee discomfort and compared with glucosamine and chondroitin.
Lugo J.P. et al. (2016), Nutr J 15:14Preliminary evidence · animal study
Turmeric (THC)110 mg
In animal models, the curcumin metabolites tetrahydro- and octahydrocurcumin inhibited the TAK1-NF-κB pathway more strongly than curcumin.
Zhang Y. et al. (2018), Front Pharmacol 9:1181Preliminary evidence · research review
Boron2 mg
A review of research on boron: bones and the metabolism of vitamin D and magnesium.
Pizzorno L. (2015), Integr Med 14(4):35-48Strong evidence · EU-authorized claim
Biotin2000 µg
Biotin contributes to the maintenance of normal hair.
Commission Regulation (EU) No 432/2012+2 more footnotes
- Research review
Review: biotin deficiency shows up as hair loss, among other signs; data on supplementation in people without a deficiency are limited.
Patel D.P. et al. (2017), Skin Appendage Disord 3(3):166-169 - Limits and interactions
Warning: biotin can interfere with lab test results, including troponin and thyroid hormone tests.
US FDA, Safety Communication (2019)
Strong evidence · EU-authorized claim
Zinc15 mg
Zinc contributes to the maintenance of normal hair, nails and skin.
Commission Regulation (EU) No 432/2012+1 more footnote
- Human clinical study
In healthy adults, zinc absorption from zinc citrate was comparable to zinc gluconate and higher than from zinc oxide.
Wegmüller R. et al. (2014), J Nutr 144(2):132-136
Strong evidence · EU-authorized claim
Vitamin A800 µg
Vitamin A contributes to the maintenance of normal skin.
Commission Regulation (EU) No 432/2012Strong evidence · EU-authorized claim
Vitamin E50 mg
Vitamin E contributes to the protection of cells from oxidative stress.
Commission Regulation (EU) No 432/2012Strong evidence · EU-authorized claim
Vitamin B150 mg
Thiamine contributes to normal energy-yielding metabolism.
Commission Regulation (EU) No 432/2012Strong evidence · EU-authorized claim
Vitamin B610 mg
Vitamin B6 contributes to the reduction of tiredness and fatigue.
Commission Regulation (EU) No 432/2012Strong evidence · meta-analysis of multiple studies
Hyaluronic acid200 mg
Review of randomized trials: oral hyaluronic acid was evaluated for the hydration of dry skin.
Kawada C. et al. (2014), Nutr J 13:70+1 more footnote
- Human clinical study
In a 12-week placebo-controlled study, 120 mg of hyaluronic acid per day was assessed for wrinkles and skin condition.
Oe M. et al. (2017), Clin Cosmet Investig Dermatol 10:267-273
Preliminary evidence · research review
Deer antler300 mg
Antler as a model of organ regeneration in mammals: periosteal stem cells and growth of up to 2 cm per day.
Price J. et al. (2005), J Anat 207(5):603-618+1 more footnote
- Research review
A review of the chemical composition of deer antler and pharmacological research on it.
Wu F. et al. (2013), J Ethnopharmacol 145(2):403-415
Preliminary evidence · research review
Terminalia chebula220 mg
A review of clinical and preclinical research on Terminalia chebula.
Bag A. et al. (2013), Asian Pac J Trop Biomed 3(3):244-252Preliminary evidence · research review
Gotu kola100 mg
A review of the uses of gotu kola (Centella asiatica) in cosmetology and dermatology.
Bylka W. et al. (2013), Postepy Dermatol Alergol 30(1):46-49Strong evidence · EU-authorized claim
Chromium200 µg
Health claims: maintenance of normal blood glucose levels and normal macronutrient metabolism.
Commission Regulation (EU) No 432/2012Strong evidence · meta-analysis of multiple studies
Berberine HCl500 mg
A systematic review of clinical studies points to an effect of berberine on glycemic and lipid parameters.
Liang et al. (2019), Endocrine Journal 66(1):51-63+1 more footnote
- Human clinical study
In a clinical study in adults with impaired glucose metabolism, berberine lowered selected markers of glycemia.
Yin et al. (2008), Metabolism 57(5):712-7
Strong evidence · meta-analysis of multiple studies
Ceylon cinnamon100 mg
Meta-analysis of studies on cinnamon and glycemic parameters.
Allen et al. (2013), Annals of Family Medicine 11(5):452-9Strong evidence · human clinical study
White mulberry200 mg
White mulberry leaf extract taken with a meal was studied for the post-meal glucose response.
Riche et al. (2017), Phytotherapy Research 31(8):1149-1162Preliminary evidence · research review
Bitter melon200 mg
A review of research on the bioactive compounds of bitter melon and their relevance to metabolism.
Salehi et al. (2019), Biomolecules 9(10):551Strong evidence · meta-analysis of multiple studies
Saccharomyces boulardii2,11×10¹⁰ CFU
A systematic review of studies with S. boulardii in adults.
McFarland L.V. (2010), World J Gastroenterol 16(18):2202-2222Moderate evidence · human observational study
Bifidobacterium longum3,34×10¹⁰ CFU
In a study of more than 300 Japanese people aged 0 to 104, the share of bifidobacteria in the microbiota decreased with age.
Odamaki T. et al. (2016), BMC Microbiol 16:90Preliminary evidence · laboratory study
Burdock root100 mg
In a laboratory study, burdock extract was studied for the survival of L. acidophilus and B. bifidum strains.
Kamkar E.A. et al. (2023), Food Sci NutrPreliminary evidence · research review
Lactobacillus rhamnosus7,26×10¹⁰ CFU
A review of the properties of L. rhamnosus and research directions for its strains.
Mathipa-Mdakane, Thantsha (2022), FoodsPreliminary evidence · research review
Bifidobacterium bifidum3,46×10¹⁰ CFU
A review of B. bifidum biology as a key member of the early human microbiota.
Turroni F. et al. (2019), MicroorganismsPreliminary evidence · research review
Bacillus coagulans3,43×10¹⁰ CFU
A review of Bacillus probiotics: spores, survival and applications.
Cutting S.M. (2011), Food Microbiol 28(2):214-220+1 more footnote
- Research review
A review of research on B. coagulans.
Mu Y., Cong Y. (2019), Beneficial Microbes
Preliminary evidence · research review
Clostridium butyricum1,30×10⁸ CFU
Review: C. butyricum as a butyrate-producing symbiont.
Stoeva M. et al. (2021), Gut MicrobesPreliminary evidence · research review
FOS121 mg
ISAPP consensus: definition of a prebiotic as a substrate selectively utilized by host microorganisms.
Gibson G.R. et al. (2017), Nat Rev Gastroenterol Hepatol 14:491-502Preliminary evidence · research review
Asafoetidain the blend
A review of research on asafoetida.
Shaikh B. et al. (2025), J Drug Deliv TherPreliminary evidence · laboratory study
Sodium butyrate1200 mg per day
Isolated human colonocytes derived about 70% of their energy from butyrate, more than from glucose or glutamine.
Roediger W.E. (1980), Gut 21(9):793-798+1 more footnote
- Research review
A review of the role of butyrate in the colon: epithelial energy, the barrier, the inflammatory response and oxidative stress.
Hamer H.M. et al. (2008), Aliment Pharmacol Ther 27(2):104-119
Preliminary evidence · laboratory study
Butyric acid960 mg
In a Caco-2 cell model, butyrate supported tight junction assembly via AMPK activation.
Peng L. et al. (2009), J Nutr 139(9):1619-1625+1 more footnote
- Research review
A review of the pathways by which gut bacteria produce propionate and butyrate.
Louis P., Flint H.J. (2017), Environ Microbiol 19(1):29-41
Preliminary evidence · laboratory study
BPC-157 · soft tissue1 capsule
In tendon fibroblast cultures, BPC-157 increased cell survival and migration via the FAK-paxillin pathway.
Chang C.H. et al. (2011), J Appl Physiol 110(3):774-780+1 more footnote
- Research review
A review of research on BPC-157 in the healing of musculoskeletal soft tissue (tendons, ligaments and muscles), mainly in animal models.
Gwyer D., Wragg N.M., Wilson S.L. (2019), Cell Tissue Res 377(2):153-159
Preliminary evidence · laboratory study
BPC-157 · blood vessels1 capsule
BPC-157, VEGFR2 activation and angiogenesis in a cell model and in rats.
Hsieh M.J. et al. (2017), J Mol Med 95(3):323-333The studies concern the ingredients, not the products. Where the EU has not authorized health claims, we write “studied for” and describe what was studied instead of promising an effect.
The people behind the formula.
Athletes, scientists and specialists we consult on formulations, doses and the way we describe our products. Each of them asks as much of us as you ask of yourself.
Tomasz SararaKickboxing world champion
WKN world champion · MSc, Academy of Physical Education (AWF)
Strength, discipline and experience from the professional ring. He combines a sports education with hands-on knowledge of intense training and recovery.
Dr Rafal ZiewieckiPhD in Chemistry
Chemistry and ingredient analysis
At Synthagen
He assesses the properties of ingredients and how they interact, supporting the development of stable formulas.
Andrzej Kowalski, MScIngredients and formulation quality
At Synthagen
He assesses ingredient selection and supports formula development in terms of quality, stability and the manufacturing process.
Choose your formula.
Every formula on this page, with the technology, dose and evidence you’ve just seen. You have 90 days to decide.
★★★★★4.9 · 50 reviews
GUT BALANCE™Synbiotic
- 8 strains, each in its own microcapsule
- No refrigeration needed
- Strongest evidence: meta-analysis (S. boulardii)
€49,99
★★★★★4.9 · 50 reviews
PURE BUTYRATE™Sodium butyrate
- 1200 mg sodium butyrate per day
- Odorless micropellets, gradual release
€49,99
★★★★★4.9 · 50 reviews
PURE OXILLIGENCE™8 antioxidants
- Resveratrol: 2× the study dose
- Phytosome quercetin
- 4 ingredients backed by clinical studies
€49,99
★★★★★4.9 · 50 reviews
VITAL OMEGA PRO™Omega-3 + D3 + K2
- 490 mg EPA + DHA: 2× the EU claim threshold
- Oil and pellets in one capsule
- 4 EU health claims
€49,99
★★★★★4.9 · 50 reviews
NOVA CELLCARE™Skin, hair & nails
- Hyaluronic acid: 1.7× the study dose
- Biotin, zinc, vit. A: EU claims for skin and hair
€69,99
★★★★★4.9 · 61 reviews
GLUCO AGEPROTECT™Metabolism
- Berberine 500 mg
- Chromium: EU claim on blood glucose levels
€49,99
★★★★★4.9 · 38 reviews
NL-BPC-157™Hexadecapeptide
- Double capsule with enteric coating
- Two international patent applications
- Bestseller
€56,99
Not sure where to start?
Gut, recovery, skin, metabolism, longevity. Choose a goal and we’ll show you the formulas made for it.
Find by goal
See for yourself. You have 90 days.
Choose a formula, take it every day and judge the results. If it doesn’t work for you, we’ll refund you, even for an opened package.
Every batch testedLabs in PL, DE and CH.
Ships in 24hMade in the EU, dispatched from Poland.
Full ingredient listEvery dose stated on the label.
Before you ask.
What if the product isn’t right for me?
You have 90 days to decide. If the product isn’t right for you, we’ll refund you, even for an opened package.
Which product should I start with?
Start with your goal: gut, recovery, skin, metabolism or longevity. The formula finder on our home page will show you the products made for it.
Why do your supplements cost more?
You pay for a form matched to each ingredient (phytosomes, micropellets, microcapsules, the NL-DELIVERY™ double capsule) and for doses backed by research. We show them on this page, ingredient by ingredient.
When will I get my order?
We process orders within 24 hours and ship from our warehouse in Poland. EU delivery usually takes 2–7 business days.
Can I take the products with medication?
Some ingredients, e.g. grapefruit in PURE OXILLIGENCE™, may interact with medication. If you take any medication, consult your doctor or pharmacist before buying.
Why do you write “studied for” with peptides?
The EU has not authorized any health claims for peptides. So instead of promising an effect, we describe what was studied and what kind of studies they were.