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The proportion of bifidobacteria in the gut declines with age. For people who plan their health for decades and start with their gut.
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An advanced synbiotic designed for microbiota balance and everyday gut comfort.An advanced synbiotic designed for microbiota balance and everyday gut comfort. It combines 8 microbial cultures (approx. 289 billion CFU), the prebiotic FOS and plant extracts. A multi-ingredient formula developed for people who want to take conscious care of their gut, especially during periods of increased strain on the body.
8 microbial cultures, approx. 289 billion CFU. Different microorganisms can act on the gut in different ways, supporting fermentation processes and microbial balance. For you, this means a multi-directional approach to gut care, aimed at more comfortable everyday function.
121 mg FOS, food for beneficial bacteria. A prebiotic that selected gut bacteria can use, supporting their activity. This means the formula goes beyond supplying microorganisms and also takes into account the environment they live in.
Each culture microencapsulated separately. The protective technology helps limit the adverse effects of storage conditions and passage through the stomach. As a result, more of the microorganisms supplied can stay viable and reach the site of their potential action.
90-day money-back guarantee. You have time to add GUT BALANCE™ to your routine and judge whether it meets your needs, with no risk of losing your money.
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“The best part is that I can immediately see a specific detail: ribwort plantain and asafoetida. That lets me assess the formula...”
“Two capsules a day are easier for me to remember than a complicated schedule. Plus, microcapsules as part of the technology.”
“I'm curious about one particular ingredient or detail: combining microbial cultures and a prebiotic in one formula. The other aspects of the...”
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Food supplements should not be used as a substitute for a varied diet. A balanced diet and a healthy lifestyle are recommended. For adults only. Do not exceed the recommended daily dose. Contains yeast (Saccharomyces boulardii).
Three areas brought together in one formula: a complete ecosystem in a capsule, the microbiota as an organ, and the science of dysbiosis.
GUT BALANCE™ combines microbial cultures, the prebiotic FOS, plant extracts and microencapsulation technology. Each element plays a different role, creating a multi-directional formula developed to support the gut microbiota.
The four building blocks of the formulaDifferent microorganisms with different biological properties. Instead of building the formula around a single culture, you give your gut a multi-component blend that supports its microbial environment.
It serves as food for selected beneficial bacteria. This means the formula not only supplies microorganisms but also includes an ingredient that can support their activity.
Burdock, ribwort plantain, Terminalia bellirica and asafoetida provide plant compounds with potential biological activity, adding further mechanisms of action to the formula.
A technology designed to protect the viability of microorganisms from adverse conditions. It matters for how many of them can survive the journey through the digestive tract.
Bloating, excess gas, a feeling of heaviness after meals or irregular bowel movements may be linked to how your gut microbiota functions. Bacteria are involved in breaking down food components, in fermentation and in producing substances that affect how the gut works. That’s why caring for their balance is an important part of looking after your everyday digestive comfort.
Five areas where the microbiota affects digestionGut bacteria are involved in fermenting undigested food components. The type and intensity of these processes affect how much gas is produced.
What does this mean for you?Normal fermentation may contribute to less discomfort and a less bloated, tense feeling in your abdomen after meals.
The microbiota produces metabolites that act on the gut environment and may be involved in regulating gastrointestinal motility.
What does this mean for you?Supporting normal gut function may contribute to a more predictable bowel rhythm and greater comfort throughout the day.
Gut bacteria help break down certain food components that the body cannot digest on its own, including some types of fiber. Fermentation produces short-chain fatty acids, among other things.
What does this mean for you?A well-functioning microbiota helps your body make use of some dietary components that would otherwise remain undigested.
How you feel after eating is influenced by gut motility, food fermentation and the sensitivity of the digestive tract, among other factors. The microbiota is one of the elements involved in these processes.
What does this mean for you?Caring for your gut environment can be part of an approach aimed at reducing feelings of heaviness, fullness and discomfort after eating.
The gut communicates with the nervous system via the gut–brain axis. Stress can affect gut motility, gut sensitivity and digestive processes.
What does this mean for you?Coping better with digestive complaints can mean fewer moments when your stomach gets in the way of work, travel or everyday activities.
The gut is much more than the system responsible for digestion. It is involved in nutrient absorption, immune regulation, metabolism and communication with the brain. Its condition matters for how your whole body functions, whether you train hard, do mentally demanding work, live with stress or simply want to stay in good shape for years to come.
Four areas where your gut supports your bodyThe small intestine is responsible for absorbing the nutrients needed to produce energy. The gut microbiota is also involved in metabolizing some dietary components.
What does this mean for you?Normal gut function helps your body make use of the energy and nutrients supplied by food, whether you need them for work, training or daily responsibilities.
The gut is an important site of immune system activity. The microbiota is involved in regulating it, and the gut barrier helps limit the body’s contact with unwanted substances.
What does this mean for you?Caring for your gut is part of looking after your body’s natural protective mechanisms, especially with a demanding lifestyle.
The gut and the brain are in constant two-way communication via the nervous system, hormones and microbial metabolites. Stress can affect how the gut functions, and signals from the digestive tract reach the brain.
What does this mean for you?Gut condition is one element of overall wellbeing. This is especially important when you combine demanding work, stress and countless daily responsibilities.
The microbiota is involved in metabolizing food components and producing compounds that affect metabolic processes. Its composition changes with age, diet and lifestyle.
What does this mean for you?Looking after your gut is part of caring for your health in the long term, both while you are young and active and when you want to stay fit in the decades ahead.
A complete ecosystem instead of a single strain. While standard probiotics provide a single strain without “fuel”, GUT BALANCE™ delivers a probiotic, a prebiotic and phytonutrients in one daily serving. We designed the formula to meet the expectations of the most demanding.

The proportion of bifidobacteria in the gut declines with age. For people who plan their health for decades and start with their gut.

For people who live at full speed, face chronic stress every day and want to look after their gut, the foundation of their everyday wellbeing.

A high-protein diet and intense exercise also put a strain on the gut. For people who care for their microbiota as much as their fitness.
What can your body gain?
Regular use of GUT BALANCE™ is part of daily care for your gut microbiota. Below are the potential benefits worth watching for over the following weeks of supplementation.
CFU per daily serving, from 8 separately microencapsulated strains.
Plus 121 mg FOS and 4 plant extracts.
You may start to feel less digestive discomfort after everyday meals. The feeling of heaviness, fullness and abdominal tension may gradually ease. You may notice the first positive changes in the regularity of your bowel movements.
Bloating and excess gas may become less bothersome, making it easier to enjoy meals without worrying about discomfort afterwards. You may feel less urgency and notice more predictable bowel function. Fewer digestive complaints can mean more freedom at work, in meetings and while traveling.
If gut complaints ease, you may feel freer and better throughout the day. Your stomach may distract you less often from work, training and daily responsibilities. You may notice that digestive comfort becomes more consistent, even on more demanding days.
You may feel a clearer difference in your everyday comfort if digestive problems used to bother you. Fewer gut complaints may translate into better wellbeing and more freedom in an active life. Regular gut care becomes part of your long-term approach to health, fitness and quality of life.
Bacterial cultures, yeast, a prebiotic and plant extracts in one serving, with the CFU of every strain on the label. A typical probiotic is bacteria alone.
| What matters | GUT BALANCE™ | Separate products | Typical probiotic |
|---|---|---|---|
| Lactic acid bacteria and bifidobacteria strains | 5 strains | Several jars | Usually 1–3 |
| Bacillus coagulans (spores) | 3,43×10¹⁰ CFU | Separate jar | Rarely |
| Saccharomyces boulardii yeast | 2,11×10¹⁰ CFU | Separate jar | Rarely |
| Clostridium butyricum (butyrate) | 1,30×10⁸ CFU | Separate jar | Rarely |
| FOS prebiotic | 121 mg | Separate jar | Rarely |
| Plant extracts | 4 extracts | 4 jars | — |
| Microencapsulation of every strain | Yes | Depends on the brand | Depends on the brand |
| CFU of every strain on the label | Yes | Depends on the brand | Often only the total |
CFU of each on the label
at the time of manufacture
Zero fillers
Test the formula for yourself
Stomach acid, moisture and heat are the three main enemies of live cultures. That’s why each of the 8 strains is microencapsulated separately, with the prebiotic FOS in the same capsule.
Each strain is sealed in its own microcapsule, which protects it from stomach acid, moisture and degradation.
Every bacterium has its own shell.
Fructooligosaccharides are not digested in the small intestine. In the colon, they are fermented by Bifidobacterium and Lactobacillus strains.
The bacteria get food for the journey.
According to the manufacturer, microencapsulation allows the product to be stored at room temperature for up to 2 years.
The jar can sit in your cupboard.
Illustrative diagram. The description of the technology comes from the manufacturer. There are no EU-authorized health claims for probiotics, so we describe the technology, not the product’s effects.
13 ingredients along the route through the digestive tract: from protection in the stomach to the barrier of the large intestine.
Stomach acid reduces the survival of cultures. This is where the microcapsules and protective ingredients do their work.
Lactic acid bacteria and yeast lower the pH and compete with unfavorable microorganisms.
Bifidobacteria ferment FOS and inulin from burdock into short-chain fatty acids.
Butyrate fuels the cells of the colon lining, which form the gut barrier.
Blend of 8 cultures · 209 mg complex
CFU: colony-forming units, at the time of manufacture. Values per 2 capsules.
121 mgPrebiotic: short chains of fructose that human enzymes cannot digest. They reach the colon, where they are fermented by bacteria.
100 mgA root rich in inulin, a natural prebiotic fiber. Studied in relation to the survival of probiotic cultures.
80 mgLeaves rich in plant mucilage, traditionally used as a protective, coating ingredient.
50 mgFruit rich in tannins, including gallic acid. One of the three fruits in the Ayurvedic blend triphala.
in the blendA resin from the root of Ferula, a spice in Indian cuisine traditionally added to legume dishes.
Expand an ingredient to see its mechanism and the research behind it.
L. rhamnosus (now Lacticaseibacillus rhamnosus) is a lactic acid bacterium naturally present in the digestive tract. Its strains are being studied for their survival in the digestive tract and adhesion to the intestinal lining, among other things.
Mechanism: A lactic acid bacterium, one of the best-studied probiotic species.
A review of the properties of L. rhamnosus and of research directions on its strains.
Mathipa-Mdakane, Thantsha (2022), Foods (publication cited by the manufacturer)L. acidophilus is one of the classic probiotic species, found in fermented dairy products. The lactic acid it produces lowers the pH, creating less favorable conditions for some microbes.
Mechanism: A lactic acid bacterium that ferments sugars into lactic acid and lowers the pH of its environment.
Research on L. acidophilus strains and their properties.
Gao H. et al. (2022), J Microbiol Biotechnol (publication cited by the manufacturer)B. longum is one of the most common bifidobacteria in humans. It ferments oligosaccharides, including FOS, into acetate and lactate, which other bacteria then convert further, including into butyrate.
Mechanism: Bifidobacteria dominate the gut in early life, and their share declines with age.
In a study of more than 300 Japanese people aged 0 to 104, the proportion of bifidobacteria in the microbiota decreased with age.
Odamaki T. et al. (2016), BMC Microbiol 16:90B. bifidum is one of the first species to colonize the infant gut. It can break down intestinal mucus glycans, and the resulting products are also used by other bacteria.
Mechanism: A bifidobacterium able to break down intestinal mucus and share the products with other bacteria.
A review of B. bifidum biology as a key member of the early human microbiota.
Turroni F. et al. (2019), Microorganisms (publication cited by the manufacturer)B. coagulans (now Weizmannia coagulans) produces lactic acid but, unlike Lactobacillus, forms spores. This form is resistant to low pH and drying, which makes it easier for it to pass through the stomach.
Mechanism: A spore-forming bacterium; spores are resistant to stomach acid and high temperatures.
A review of Bacillus probiotics: spores, survival and applications.
Cutting S.M. (2011), Food Microbiol 28(2):214-220A review of research on B. coagulans.
Mu Y., Cong Y. (2019), Beneficial Microbes (publication cited by the manufacturer)S. boulardii is the only yeast widely used as a probiotic. Because it is not a bacterium, antibacterial antibiotics do not affect it, which is why it is studied in the context of antibiotic therapy.
Mechanism: A probiotic yeast. As a fungus, it is not sensitive to antibacterial antibiotics.
A systematic review of S. boulardii studies in adults.
McFarland L.V. (2010), World J Gastroenterol 16(18):2202-2222Alongside Lactobacillus bulgaricus, S. thermophilus is the main bacterium in yogurt fermentation. It produces β-galactosidase, an enzyme that breaks down lactose.
Mechanism: A yogurt-fermenting bacterium that breaks down lactose into lactic acid.
Research on S. thermophilus and the immune system.
Kobayashi K. et al. (2025), Front Immunol (publication cited by the manufacturer)C. butyricum is a gut bacterium that produces butyrate, the main energy source for the cells of the colon lining. It forms spores, which allow it to survive passage through the stomach.
Mechanism: An anaerobic, spore-forming bacterium that produces butyrate.
Review: C. butyricum as a butyrate-producing symbiont.
Stoeva M. et al. (2021), Gut Microbes (publication cited by the manufacturer)Butyrate and oxygen: epithelial cells consume butyrate, which keeps oxygen levels in the gut low, favoring anaerobic bacteria.
Kelly C.J. et al. (2015), Cell Host Microbe 17(5):662-671FOS occur naturally in onions, garlic, leeks and bananas, among other foods. Prebiotic studies usually use doses of several grams per day, so the 121 mg in the formula serves as food accompanying the cultures, not as a standalone prebiotic dose.
Mechanism: Prebiotic: short chains of fructose that human enzymes cannot digest. They reach the colon, where they are fermented by bacteria.
ISAPP consensus: definition of a prebiotic as a substrate selectively utilized by host microorganisms.
Gibson G.R. et al. (2017), Nat Rev Gastroenterol Hepatol 14:491-502Research on FOS and their effect on the microbiota.
Singh P. et al. (2025), Food Bioscience (publication cited by the manufacturer)Greater burdock is a biennial plant whose root is eaten as a vegetable in Asia (gobō). It contains inulin and polyphenols, including chlorogenic acid.
Mechanism: A root rich in inulin, a natural prebiotic fiber. Studied in relation to the survival of probiotic cultures.
In a laboratory study, burdock extract was investigated in relation to the survival of L. acidophilus and B. bifidum strains.
Kamkar E.A. et al. (2023), Food Sci Nutr (publication cited by the manufacturer)Research on burdock root as a functional food ingredient.
Moro T., Clerici M. et al. (2021), Food Res Int (publication cited by the manufacturer)Ribwort plantain is a common meadow plant. Its leaves contain mucilage, iridoids (including aucubin) and polyphenols. In traditional herbal medicine, it was used for its protective, coating properties.
Mechanism: Leaves rich in plant mucilage, traditionally used as a protective, coating ingredient.
Research on Plantago compounds and the gut microbiota.
Wu Y. et al. (2025), Mol Nutr Food Res (publication cited by the manufacturer)Terminalia bellirica (bahera) is a tree native to South Asia. Its fruit, together with amla and Terminalia chebula, makes up triphala, one of the best-known Ayurvedic blends. The fruit contains tannins and gallic acid.
Mechanism: Fruit rich in tannins, including gallic acid. One of the three fruits in the Ayurvedic blend triphala.
Research on Terminalia bellirica compounds.
Li Y. et al. (2023), Molecules (publication cited by the manufacturer)Research on Terminalia bellirica in models of the digestive tract.
Zou Y. et al. (2025), J Ethnopharmacol (publication cited by the manufacturer)Asafoetida is the dried resin from the roots of plants of the genus Ferula. In Indian cuisine, it is added to lentil and bean dishes, and in traditional medicine it was used for digestive problems.
Mechanism: A resin from the root of Ferula, a spice in Indian cuisine traditionally added to legume dishes.
A review of research on asafoetida.
Shaikh B. et al. (2025), J Drug Deliv Ther (publication cited by the manufacturer)The studies concern species and selected strains, not the product. There are no EU-authorized health claims for the ingredients in this formula, so we only describe what they are being studied for.
Your everyday form also starts in your gut. The gut is much more than digestion. It is where the body absorbs the nutrients needed to produce energy, and the microbiota is involved in metabolic and immune processes and in communication with the brain. That’s why looking after your gut matters not only for comfort after meals, but also for long-term health and everyday functioning.
The gut and the brain communicate via the nervous system, hormones and substances produced by microorganisms. The microbiota may influence pathways related to serotonin, the stress response and nerve signaling.
What does this mean for you?Gut condition is one element of good mental and physical wellbeing, especially when you live with stress, do mentally demanding work and need to stay focused for hours on end.
The small intestine is responsible for absorbing proteins, fats, carbohydrates, vitamins and minerals. The microbiota also ferments some fiber, producing compounds involved in energy balance and metabolic regulation.
What does this mean for you?A well-functioning digestive tract helps your body use the nutrients it needs for work, physical activity, recovery and daily responsibilities.
The microbiota is involved in regulating the immune system and in the function of the gut barrier. Research also examines the links between the microbiota, inflammatory processes and skin condition, known as the gut–skin axis.
What does this mean for you?Caring for your gut is one part of looking after your body’s natural protective mechanisms, overall condition and healthy aging.
Whether you’re building a career, training hard, raising children or want to stay in good shape for decades to come, normal gut function is an important part of your health.
GUT BALANCE™ is a synbiotic developed so that live bacterial cultures can reach the gut, a process supported by the prebiotic FOS and plant extracts that help the bacteria survive. Each strain was selected on the basis of research and assigned a specific role in the digestive system.
The formula is backed by 17 cited scientific publications: peer-reviewed in vivo and in vitro studies on each strain, the prebiotic and each extract separately. Every batch is analyzed in accredited European laboratories for purity and culture viability.
This is not a “mix of bacteria in the hope that it works”. It is a formula designed ingredient by ingredient, mechanism by mechanism. Precise strain selection, purity and consistent quality are the SYNTHAGEN standard.
Reviews come from our store’s customers. Individual experiences may vary.
The best part is that I can immediately see a specific detail: ribwort plantain and asafoetida. That lets me assess the formula for myself. The only downside is remembering to fit two capsules a day into my routine.
Two capsules a day are easier for me to remember than a complicated schedule. Plus, microcapsules as part of the technology.
I'm curious about one particular ingredient or detail: combining microbial cultures and a prebiotic in one formula. The other aspects of the formula are described too, and I always read the label warnings.
What caught my attention? The combination of microbial cultures and a prebiotic in one formula. What made me read the description more closely? Approximately 289 billion CFU per serving, as declared at the time of manufacture.
I wanted a straightforward answer about what the daily serving contains. The label gives specifics: microencapsulated cultures and four plant ingredients. For me, that matters more than big claims on the front.
The best part is that I can immediately see a specific detail: ribwort plantain and asafoetida. That lets me assess the formula for myself. The only downside is remembering to fit two capsules a day into my routine.
Two capsules a day are easier for me to remember than a complicated schedule. Plus, microcapsules as part of the technology.
I'm curious about one particular ingredient or detail: combining microbial cultures and a prebiotic in one formula. The other aspects of the formula are described too, and I always read the label warnings.
What caught my attention? The combination of microbial cultures and a prebiotic in one formula. What made me read the description more closely? Approximately 289 billion CFU per serving, as declared at the time of manufacture.
I wanted a straightforward answer about what the daily serving contains. The label gives specifics: microencapsulated cultures and four plant ingredients. For me, that matters more than big claims on the front.
Creators sharing their experiences with Synthagen.

Gracjan Szostak@szostak_gracjan
Marlena Jarmasz@marlenajarmasz
Krystian Kipiel@trenuj_z_krystianem
Wiktoria Różańska@thoria.fitness
Maciej Szot@czajebaze
Paulina@paulina.j_m
Ilona Kwiecińska@kwiecinskailona
Patryk Chmura@rozchmurz_sie
Patryk Chmura@rozchmurz_sie1, 3 or 5 jars. The larger the set, the lower the price per jar.
Once a day, ideally with a meal and a glass of water.
30 servings per jar. A set of 3 covers 90 days.
90-day money-back guarantee. Take GUT BALANCE™ regularly and see how it fits into your routine. If it’s not for you, the money-back guarantee has you covered. Refund policy.
Add to cartDidn’t find the answer to your question? Write to us: [email protected]
Buy GUT BALANCEThe intestinal lining is a single layer of cells that renews itself every few days, and it needs energy to do so. Two products supply butyrate, its main fuel: one through bacteria, the other ready-made. The third is a peptide that has been studied for more than 30 years in relation to the gastrointestinal mucosa.
The amount of butyrate from fermentation depends on the fiber in your diet and the composition of your microbiota, so it varies from person to person. Ready-made butyrate from PURE BUTYRATE™ does not depend on fermentation. The pair combines both sources.
BPC-157 is a fragment of a protein found in gastric juice, and it is stable in acid. The first studies concerned the gastric mucosa, later ones the small and large intestine. These are animal and cell studies, and they concern BPC-157, not this product. Human studies are scarce.
No ingredient is repeated across the three products. NL-BPC-157™ in the morning on an empty stomach, GUT BALANCE™ and PURE BUTYRATE™ with a meal. Each jar lasts 30 days, so all three run out on the same day.



Sources: Roediger W.E., Gut 1980;21(9):793-798 (butyrate as an energy source for colonocytes). Stoeva M. et al., Gut Microbes 2021 (C. butyricum produces butyrate). Sikiric P. et al., J Physiol Paris 1993;87(5):313-327 (first description of BPC-157). Sikiric P. et al., Curr Pharm Des 2011;17(16):1612-1632 (BPC-157 in gastrointestinal research). Research on BPC-157 is mainly in animal and cell models. The products have not been shown to treat any disease. Food supplements are not a substitute for a varied diet. If you take medication or have a chronic condition, consult your doctor before use.
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