NL-SELANK™

Selank was developed in Russia, where most of the research has been carried out: in animals and in small groups of people.¹

1. Easier to stay calm

   Preliminary studies, conducted mainly in Russia, suggest less tension in situations that usually throw you off balance.¹

2. Taken during the day

   You take the capsules when tension tends to peak: at work, on the go or before an important conversation.

3. Tasteless and odorless

   Two capsules a day, taken with water. Sealed in a capsule, the peptide has no taste or smell.

Five mechanisms that scientists are examining in research on Selank, stress and mood.

1. 1Tuftsin analog

   You support the system that links immunity with the stress response.

   Tuftsin is a short peptide that the body produces on its own in the immune system. Selank is its synthetic analog. Peptides from this family have been studied in animal models of stress.²

2. 2Serotonin and mood

   You support the system that mood and calm depend on.

   Serotonin is a neurotransmitter that, among other things, influences mood. Using two strains of mice, scientists examined how Selank affects serotonin and related brain messengers known as monoamines.³

3. 3GABA and calming neurons

   You support the mechanism that helps your brain return to balance after tension.

   GABA is a neurotransmitter that calms excessive neuronal activity. In a study in rats, Selank changed the activity of several dozen genes linked to signal transmission in the brain. The pattern of these changes resembled the action of GABA.⁴

4. 4Enkephalins and the stress response

   You support peptides your body makes on its own in difficult moments.

   Enkephalins are peptides that the body produces, among other things, in response to stress. In a laboratory study on human blood serum, Selank inhibited the enzymes that break them down.⁵

5. 5BDNF in the hippocampus

   You support the brain region responsible for memory and for regulating the stress response.

   The hippocampus is the brain region responsible for memory. It is among the first to feel the effects of long-term stress. BDNF is a protein that helps neurons form new connections. In a study in rats, Selank given intranasally influenced BDNF production in the hippocampus.⁶

Scientists are also studying Selank in relation to immunity and immune system function. Here we describe areas of research. A food supplement is not intended to treat or prevent disease.

• The stress axis

  The hypothalamus and pituitary gland in the brain, together with the adrenal glands, trigger the stress response. When this system runs nonstop, it’s harder for the body to return to balance.⁷

• Work and decisions

  The prefrontal cortex, the front part of the brain, is responsible for planning and emotional control. Under severe stress, it works less effectively.⁸

• Chronic stress

  Long-term stress changes how the hippocampus and prefrontal cortex work. Some of these changes reverse once the stress passes.⁹

• Sleep

  Too little sleep impairs attention, short-term memory and judgment after just one night.¹⁰

• Immunity

  Chronic stress weakens the immune response. The nervous and immune systems constantly exchange signals.¹¹

• Neurotransmitters

  Serotonin and GABA are neurotransmitters that regulate tension and mood. Scientists have studied Selank in relation to both systems.^3,4

• Brain plasticity

  BDNF, a protein that supports neurons, helps them adapt to strain. Chronic stress lowers its levels in the hippocampus.¹²

• Stress at every age

  Stress affects the brain differently in childhood, adulthood and older age.¹³