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Home / NL Peptides / NL-EPITHALON™
Who it’s for
When is supplementation worth considering?
- You wake up tired even after a full night’s sleep
- After 40, you wake up less rested than you used to
- You work shifts or often change time zones
- You want to look after your sleep and age healthily
Peptides · Sleep · Circadian rhythm4.81· 31 reviews
NL-EPITHALON™
NL-EPITHALON™ delivers 1800 mcg of pentapeptide per day. Scientists are studying this peptide in relation to sleep, circadian rhythm and aging processes.Your body recovers while you sleep, yet with age you wake up rested less and less often. NL-EPITHALON™ delivers 1800 mcg of pentapeptide per day. Scientists are studying this peptide in relation to sleep, circadian rhythm and aging processes. The NL-DELIVERY™ capsule protects it from stomach acid and digestive enzymes, so the peptide reaches the intestine and is absorbed there.
Melatonin at night. In a small study in older adults, Epithalon increased nighttime secretion of melatonin, the sleep hormone, and normalized its daily rhythm.
Telomerase. In a lab study on human cells, Epithalon increased telomerase activity.
Signs of aging in mice. In a mouse study, Epithalon slowed some of the changes that appear with age.
NL-DELIVERY™. The double capsule protects the peptide from stomach acid, and the micropellets help it absorb in the intestine.
15 servings per jar2 capsules daily30 capsules
€170,97€170,97
You save €0,00€56,99 per jar · €3,79 per day
One-time purchase · Secure online payments
- 15 servings2 capsules daily
- 90 days risk-freeMoney-back guarantee
- MicropelletsSee the technology →
“Awesome, excellent!”
★★★★★Anonymous · Verified purchase
“The best sleep product I've ever used”
★★★★★Urszula K. · Customer review
“A product worth recommending. Better sleep and regeneration.”
★★★★★Maria D. · Customer review
Shipping: orders processed within 24 hours, delivery cost shown in the cart (shipping policy) · Contact: [email protected]
Food supplements should not be used as a substitute for a varied diet. For adults only. Do not exceed the recommended daily dose. Do not use during pregnancy or breastfeeding. Keep out of reach of children.
Key benefits of NL-EPITHALON™.
Epithalon is modeled on a peptide from the pineal gland, a small gland in the brain that releases melatonin, the sleep hormone, in the evening. Scientists are studying it in relation to sleep, circadian rhythm and cellular aging.
01Sleep and melatonin
Epithalon was developed in Russia by Professor Vladimir Khavinson’s team. Scientists have studied it mainly in cells and animals, and in humans in small groups of older adults.1
- Melatonin in older adults
In a small study in older adults, Epithalon increased the amount of melatonin released at night and normalized its daily rhythm.2
- The pineal gland weakens with age
The pineal gland releases melatonin in the evening, which sets the timing of sleep and wakefulness. With age, it works less and less efficiently.3
- 2 capsules in the evening
You take them before bed. Enclosed in the capsule, the peptide has no taste or smell.
02Epithalon in aging research
Five areas in which scientists have studied Epithalon in relation to sleep, circadian rhythm and aging.
1Pineal gland and melatonin
You support the rhythm that sets your time for sleep and recovery.
With age, the pineal gland releases less melatonin. In older adults and in old monkeys, Epithalon increased its nighttime secretion.2
2Telomeres and telomerase
You support the processes behind cell renewal.
Telomeres are the end caps of chromosomes: they protect DNA and shorten with every cell division. Telomerase is the enzyme that rebuilds them. In a study on human fibroblasts, connective tissue cells grown in the lab, Epithalon increased telomerase activity and telomere length.4
3Signs of aging in mice
You support the processes researchers associate with slower aging.
Researchers measured signs of aging in mice, such as chromosome damage. Epithalon slowed some of these changes. Average lifespan did not change, but the longest-lived animals lived longer.5
4Pineal and pancreatic hormones
You support the hormonal system, which loses its regular rhythm with age.
In old monkeys, pineal peptides restored the hormonal function of the pineal gland and pancreas that had been disrupted with age.6
5Effects on genes
You support the processes a cell regulates at the gene level.
Professor Khavinson’s team studies how short peptides affect gene expression, that is, which genes a cell switches on and which it silences. A 2021 review brings together results from cell and animal studies.1
Scientists are also studying Epithalon in relation to immunity and chronic inflammation. We describe research directions here. A food supplement is not intended to treat or prevent disease.
03Sleep and the aging body
- Deep sleep
Deep sleep gets shorter with age. It is in this phase of sleep that the brain and body recover most.7
- Circadian rhythm
The biological clock, the internal system that keeps track of the 24-hour day, weakens with age. Sleep times and hormone release become less regular.8
- Melatonin
With age, the body produces less melatonin. This hormone regulates the sleep rhythm and acts as an antioxidant, neutralizing free radicals.3
- Telomeres
Telomeres, the end caps of chromosomes, shorten with age and under stress. Researchers link their length to healthy aging.9
- Cortisol and stress
Chronic stress alters the secretion of cortisol, the stress hormone, and affects the brain at any age.10
- Immunity
Sleep and the immune system influence each other. When you sleep too little, your body is less able to fend off infections.11
- Inflammation
With age, a low-grade chronic inflammation persists in the body. Scientists call it “inflammaging”, a blend of the words “inflammation” and “aging”.12
- Longevity
Pineal peptides are one line of research into how to slow cellular aging.1
Based on scientific research, these tiles describe how sleep and the body change with age. They are not claims about the effects of the product.
References
- Khavinson V.K. et al., Molecules 2021;26(22):7053, doi:10.3390/molecules26227053 (short peptides and gene expression, review)
- Korkushko O.V. et al., Adv Gerontol 2007;20(1):74-85, PMID 17969590 (pineal peptides and melatonin rhythm in older adults)
- Karasek M., Exp Gerontol 2004;39(11-12):1723-1729, doi:10.1016/j.exger.2004.04.012 (melatonin and aging)
- Khavinson V.Kh. et al., Bull Exp Biol Med 2003;135(6):590-592, doi:10.1023/A:1025493705728 (Epithalon, telomerase and telomeres in human cells)
- Anisimov V.N. et al., Biogerontology 2003;4(4):193-202, doi:10.1023/A:1025114230714 (Epithalon and biomarkers of aging in mice)
- Goncharova N.D. et al., Exp Gerontol 2005;40(1-2):51-57, doi:10.1016/j.exger.2004.10.004 (pineal peptides and hormones in old monkeys)
- Mander B.A. et al., Neuron 2017;94(1):19-36, doi:10.1016/j.neuron.2017.02.004 (sleep and aging)
- Hood S., Amir S., J Clin Invest 2017;127(2):437-446, doi:10.1172/JCI90328 (the biological clock in older age)
- Blackburn E.H. et al., Science 2015;350(6265):1193-1198, doi:10.1126/science.aab3389 (telomeres and health)
- Lupien S.J. et al., Nat Rev Neurosci 2009;10(6):434-445, doi:10.1038/nrn2639 (stress across the lifespan)
- Besedovsky L. et al., Physiol Rev 2019;99(3):1325-1380, doi:10.1152/physrev.00010.2018 (sleep and immunity)
- Franceschi C., Campisi J., J Gerontol A Biol Sci Med Sci 2014;69 Suppl 1:S4-S9, doi:10.1093/gerona/glu057 (chronic inflammation and aging)
Who is NL-EPITHALON™ for?
NL-EPITHALON™ was created for people whose sleep no longer leaves them fully rested, whether because of age, shift work or travel.
Shift work and travel
You work night shifts, often change time zones or work irregular hours. Your biological clock constantly has to readjust.
Over 45
You look after exercise and diet, and now sleep as well, because recovery shapes how you age.
Results after 90 days.
You may notice changes at night first, and later during the day.
Regular intake of the pentapeptide supports the processes behind sleep quality, circadian rhythm and recovery. Below are the changes you may notice after 14, 30, 60 and 90 days. They may differ from person to person.
1800mcg
of pentapeptide per daily serving: 2 capsules of 900 mcg each.
2 capsules once a day, in the evening.
- Day14
Calmer nights.
You may notice that you fall asleep more easily and wake up less often during the night.
If you sleep better, you may wake up with more energy in the morning.
- Day30
Regular sleep and wake times.
Evening sleepiness and morning energy may start to arrive at regular times.
That makes it easier to keep regular sleep hours, even when your schedule changes.
- Day60
More energy during the day.
After better nights’ sleep, you may have more energy and handle daytime stress more easily.
If so, better sleep carries over into your work and well-being.
- Day90
Good sleep, every day.
After three months, well-rested nights may become your new normal.
Researchers link melatonin, circadian rhythm and telomere length to healthy aging.
NL-EPITHALON™ vs typical sleep supplements.
Most sleep supplements are meant to help you fall asleep on a given night. NL-EPITHALON™ contains a peptide that scientists are studying in relation to circadian rhythm, and the double capsule protects it in the stomach.
| What matters |  NL-EPITHALON™ | Typical sleep supplements |
|---|---|---|
| Active ingredient per serving | 1800 mcg | Depends on the brand |
| Amount per capsule | 900 mcg | Depends on the brand |
| Form | Micropellets | Capsule, tablet or gummy |
| Capsule-in-capsule | Yes | Rarely |
| Ingredients | One peptide | Melatonin or a herbal blend |
| Research focus | Circadian rhythm and aging | Falling asleep |
| Every batch tested | Yes | Depends on the brand |
| Capsules per day | 2, in the evening | 1–3 |
900mcg
active substancePentapeptide per capsule
30
capsules per pack15 servings of 2 capsules
NL
NL-DELIVERY™ technologyCapsule-in-capsule with micropellets
1
active peptideNo blend of extracts
A peptide that withstands digestion.
Stomach acid and digestive enzymes break down most peptides before the body can absorb them. That’s why we enclose the pentapeptide in micropellets, and the micropellets in a double capsule with a coating that dissolves only in the intestine. We call this system NL-DELIVERY™.
The peptide’s journey through the digestive tract.
Enteric coatingprotects the peptide in the stomach
Micropelletsrelease the peptide in the intestine
Bloodthe peptide passes into the bloodstream
micropelletreleased peptideIllustrative diagram, not to scale
Discover the ingredients of the NL-EPITHALON™ food supplement.
The capsule contains one active ingredient: the pentapeptide. The micropellets and the double capsule are designed to deliver it to the intestine and help it get absorbed.
1800 mcg pentapeptide
Daily serving: 2 capsules
No reference intake (RI), the recommended daily amount, has been established for the pentapeptide. The bars show the proportion of the daily serving.
1800 mcg per dayPentapeptide
A peptide from NL-PEPTIDES™ technology, modeled on epithalamin, a peptide from the pineal gland. Scientists are studying it in relation to circadian rhythm and aging.
Element NL-DELIVERY™Micropellets
They contain an absorption enhancer and an ingredient that lowers pH in the intestine. They help the peptide pass into the blood.
NL-DELIVERY™Double capsule
A capsule-in-capsule with an enteric coating. It opens only in the intestine, so stomach acid doesn’t destroy the peptide.
Ingredients backed by research.
Expand an item to see how it works.
Pentapeptide (epithalamin analog)1800 mcg · 2 capsules of 900 mcg
Epithalon was developed in Russia as a synthetic analog of epithalamin, a peptide from the pineal gland, the gland that releases melatonin. It was created by Professor Vladimir Khavinson’s team, which studies short peptides as bioregulators, substances that regulate how cells and organs work. In NL-EPITHALON™, the peptide goes into an NL-DELIVERY™ capsule, which protects it in the stomach. There are no EU-authorized health claims for the pentapeptide.
Mechanism: A peptide from NL-PEPTIDES™ technology, modeled on epithalamin, a peptide from the pineal gland. Scientists are studying it in relation to circadian rhythm and aging.
NL-DELIVERY™ micropelletsin every capsule
Peptides are large, water-soluble molecules, so they pass poorly through the intestinal wall. The micropellets contain an absorption enhancer that makes this passage easier, and an ingredient that lowers pH where the peptide is released. Scientists are researching absorption enhancers as one of the main approaches to oral peptide delivery.
Mechanism: The NL-DELIVERY™ component that helps the peptide pass through the intestinal wall into the blood.
Why we created NL-EPITHALON™.
Stomach acid and digestive enzymes break down most peptides before the body can absorb them. So the hardest part of any peptide supplement is getting the peptide to the intestine intact.
That’s why NL-EPITHALON™ contains a single peptide instead of a combination of melatonin and herbs. We enclosed it in micropellets and a double capsule. Every batch is tested by laboratories in Poland, Germany and Switzerland.
NL-EPITHALON™ is a single molecule, at the dose you see on the label. The SYNTHAGEN standard: pure raw material, good absorption and the same quality in every batch.
Customer reviews.
Reviews come from our store’s customers. Individual experiences may vary.
94%4- and 5-star ratings
31reviews from customers
87%5-star ratings
Verified purchase
Awesome, excellent!
A
Anonymous13.10.2026
Customer review
Na dreamThe best sleep product I've ever used
UK
Urszula K.30.07.2026
Customer review
Super!A product worth recommending. Better sleep and regeneration.
MD
Maria D.30.07.2026
Customer review
Free shippingThe product is great, but I waited 9 days for the package
IW
Irena W.30.07.2026
Customer review
I recommend it for sleepAnyone who has trouble sleeping will appreciate this
EK
Ewelina K.30.07.2026
Verified purchase
Il sonno è molto più pesante e riposante Sono curioso di vedere nel lungo periodo gli effetti sui telometri
F
Federico11.10.2026
Verified purchase
Awesome, excellent!
A
Anonymous13.10.2026
Customer review
Na dreamThe best sleep product I've ever used
UK
Urszula K.30.07.2026
Customer review
Super!A product worth recommending. Better sleep and regeneration.
MD
Maria D.30.07.2026
Customer review
Free shippingThe product is great, but I waited 9 days for the package
IW
Irena W.30.07.2026
Customer review
I recommend it for sleepAnyone who has trouble sleeping will appreciate this
EK
Ewelina K.30.07.2026
Verified purchase
Il sonno è molto più pesante e riposante Sono curioso di vedere nel lungo periodo gli effetti sui telometri
F
Federico11.10.2026
User reviews.
Creators sharing their experiences with Synthagen.
Marlena Jarmasz@marlenajarmasz
Gracjan Szostak@szostak_gracjan
Patryk Chmura@rozchmurz_sie
Paulina Idziak@haavven
Damian Powroźnik@damianpowroznik_thaikox
Wiktoria Różańska@thoria.fitness
Wiktoria Różańska@thoria.fitnessMarlena Jarmasz@marlenajarmaszGet started in three steps.
1
Take 2 capsules in the evening
Once a day, in the evening, with water.
2
Keep regular sleep hours
Go to bed and get up at similar times, weekends included. A consistent schedule helps maintain your circadian rhythm.
3
Assess after 90 days
One jar holds 15 servings, so for 90 days of regular use you need six jars.
90DAYS RISK-FREE
Try it risk-free.
90-day money-back guarantee. Take NL-EPITHALON™ regularly and see whether it fits your routine. If the product isn’t right for you, you can use the money-back guarantee. Return policy.
Add to cartFrequently asked questions.
Didn’t find the answer to your question? Write to us: [email protected]
Buy NL-EPITHALONHow do I take NL-EPITHALON™?
2 capsules once a day, in the evening, with water. Do not exceed the recommended serving. A jar contains 30 capsules, i.e. 15 servings.
Is NL-EPITHALON™ melatonin?
No. NL-EPITHALON™ contains a peptide, not melatonin. Scientists are studying it in relation to the function of the pineal gland, the gland that produces the body’s own melatonin.
What is Epithalon and where does it come from?
It’s a short peptide, a synthetic analog of epithalamin, a peptide from the pineal gland. It was developed in Russia by Professor Vladimir Khavinson’s team. Scientists are studying it in relation to circadian rhythm and aging, mainly in cells and animals.
Does NL-EPITHALON™ lengthen telomeres?
Telomeres are the end caps of chromosomes, and they shorten with age. Scientists observed increased telomerase activity and telomere length in a lab study on human cells. It is not known whether this effect occurs in humans who take the peptide orally. A food supplement is not intended to treat or prevent disease.
Can I combine NL-EPITHALON™ with other peptides?
Yes. The manufacturer suggests this combination: NL-SEMAX™ in the morning, NL-SELANK™ during the day and NL-EPITHALON™ in the evening. If you combine several peptides or take medication, check with your doctor before use.
What is NL-DELIVERY™?
It’s a capsule-in-capsule with an enteric coating and micropellets. The coating protects the peptide from stomach acid, and the micropellets release it in the intestine together with an absorption enhancer that makes absorption easier. Learn more in the Technology section.
Are there any side effects?
The manufacturer has not recorded any side effects at the recommended serving. Large human safety studies on Epithalon are lacking. If you take medication or have a chronic condition, consult your doctor before use.
How should I store the product, and who is it not intended for?
Store in a tightly closed container at room temperature, in a dry place, away from heat and light, out of reach of children. For adults only. Do not use if you are hypersensitive to any of the ingredients. Do not use during pregnancy or breastfeeding.
Three peptides for the whole day.
A set of three NL-PEPTIDES™ peptides for different times of day: NL-SEMAX™ in the morning, for mental work; NL-SELANK™ during the day, for tension; and NL-EPITHALON™ in the evening, before bed.
1NL-EPITHALON™
1800 mcg of pentapeptidein an NL-DELIVERY™ capsule
Circadian rhythmpineal gland and melatonin in studies
sleep2NL-SELANK™
Octapeptide2 capsules, during the day
Serotonin and GABAstudied in animals
calm3NL-SEMAX™
Met-octapeptide2 capsules, in the morning
BDNF and TrkBstudied in the hippocampus, the brain’s memory center
focusAround-the-clock rhythmEpithalon: in a small study in older adults, it increased nighttime melatonin secretion.Selank: in a rat study, it changed the activity of genes involved in signaling between neurons, in a way similar to GABA.Semax: in animal studies, it increased hippocampal levels of BDNF, a protein neurons need, and of its receptor TrkB.
NL-EPITHALON™ + NL-SELANK™
NL-EPITHALON™ + NL-SELANK™ + NL-SEMAX™
€113,98€170,97
Sources: Korkushko O.V. et al., Adv Gerontol 2007;20(1):74-85 (pineal peptides and melatonin rhythm). Volkova A. et al., Front Pharmacol 2016;7:31 (Selank and neurotransmission genes). Dolotov O.V. et al., Brain Res 2006;1117(1):54-60 (Semax, BDNF and TrkB in the hippocampus). Research on Epithalon, Selank and Semax comes mainly from Russia and involves animal models and small groups of people. The products have not been shown to treat any disease. Food supplements are not a substitute for a varied diet. If you take medication or have a chronic condition, consult your doctor before use.
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