English
SEMAX HAS NEUROREGENERATIVE AND NOOTROPIC EFFECTS THANKS TO:
- BDNF and NGF stimulation – increases the activity of neurotrophic growth factors, supporting neuroplasticity and neuronal regeneration.
- Enhanced cognitive function – improves working memory, focus, and learning ability.
- Neuroprotective effect – protects nerve cells from oxidative stress, hypoxia, and toxins.
- Regulation of the stress axis (HPA) – stabilizes cortisol levels and improves the body's resistance to mental and physical stress.
- Increased energy metabolism in the brain – supports the utilization of oxygen and glucose in neurons.
💡 Effect: better concentration, faster information processing, greater mental resilience and regeneration of the nervous system after exercise or stress.
SEMAX PEPTIDE STRUCTURE
- Amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Summary formula: C₃₇H₅₁N₉O₁₀S
- Molecular weight: 869,93 g/mol
- Form: white lyophilisate, water-soluble, thermally stable
BIOLOGICAL RESEARCH AND EFFECTS
SEMAX and the nervous system and memory
Studies have shown that SEMAX increases the expression of BDNF and its receptors (TrkB), which directly supports neuroplasticity and the formation of new synaptic connections. Improvements in memory, concentration, and information processing speed have been observed in animal and clinical models.
SEMAX and stress and emotional balance
SEMAX affects the hypothalamic-pituitary-adrenal (HPA) axis, normalizing cortisol levels. It has anti-stress properties, improving mental resilience and emotional stability. Clinical studies have also shown it to alleviate symptoms of fatigue and increase motivation.
Figure 1. The study shows the liver of the subject after exposure to severe stress. Images a and b are from observations after the subject was directly exposed to stress and show the liver parenchyma damaged by stress. Images c and d are from observations after administration of the Semax peptide and show a reduction in stress-induced damage. This study demonstrates the positive effect of the Semax peptide on mitigating the effects of stressful situations and reducing the body's stress itself.
SEMAX and neuroprotection and regeneration
The peptide exhibits potent antioxidant and antihypoxic properties, protecting neurons from hypoxia and oxidative damage. It supports regeneration after brain and spinal cord injuries by improving microcirculation and neuronal metabolism.
SEMAX and the circulatory system and oxygenation
SEMAX supports vascular endothelial function, improves cerebral blood flow, and improves oxygen delivery to neurons. This reduces the risk of microdamage and improves the body's aerobic capacity.
| Feature | Biological effect |
|---|---|
| Increased expression of BDNF and NGF | Regeneration and neuroplasticity |
| Improvement of cognitive functions | Better memory and concentration |
| Neuroprotective effect | Protection of nerve cells |
| Cortisol regulation | Greater resistance to stress |
| Microcirculation support | Better oxygenation and mental performance |
Bibliography
- A.Ivanov, I.Bobyntsev, O.Shepeleva, A.Kryukov, L.Andreeva, N.Myasoedov, Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress. 2017; 163;1. DOI 10.1007/s10517-017-3748-4
- O.Dołotow, E. Karpenko, L. Inozemcewa, T. Seredenina, N. Lewicka, J. Rozyczki, E.Dubynina, E,Novosadova, Semax, analog ACTH(4-10) o działaniu poznawczym, reguluje ekspresję BDNF i trkB w hipokampie szczura. 2006; 1117(1):54-60. doi: 10.1016/j.brainres.2006.07.108