CORTAGEN 10MG + BAC WATER

CORTAGEN HAS NEUROREGENERATIVE AND GEROPROTECTIVE EFFECTS THANKS TO:
  • Regulating gene expression – restoring normal nerve cell activity and inhibiting degenerative processes.
  • Stimulating neurogenesis and synaptogenesis – supporting the development of new neurons and neural connections.
  • Protecting DNA and stabilizing chromatin – acting at the epigenetic level, restoring cells to a "younger" gene expression profile.
  • Increasing neuronal resistance to oxidative stress – protecting against free radicals and inflammation.
  • Improving intercellular communication – supporting nerve conduction and cognitive function.

💡 Effect: regeneration and protection of the nervous system, support of cognitive functions, better concentration and slowing down of neurodegenerative processes.

Cortagen opakowanie synthagen laboratories Cortagen produkt synthagen laboratories

CORTAGEN PEPTIDE STRUCTURE
  • Amino acid sequence: Ala-Glu-Asp-Pro
  • Summary formula: C₁₆H₂₄N₄O₉
  • Molecular weight: 416,39 g/mol
  • Form: white lyophilisate, easily soluble in water, thermally stable
Struktura Cortagenu

BIOLOGICAL RESEARCH AND EFFECTS

CORTAGEN and the regeneration of the nervous system

Research conducted at the Institute of Bioregulation and Gerontology has shown that CORTAGEN accelerates peripheral nerve regeneration, increasing the rate of recovery by up to 30–40%. The peptide supports neuronal regeneration after injury and improves nerve conduction by acting directly on the level of gene expression in nerve cells.

CORTAGEN and epigenetics and cellular aging

CORTAGEN influences chromatin structure, enabling the activation of genes responsible for cell regeneration and inhibiting apoptosis. In vitro studies have shown that the peptide restores a "younger" DNA expression profile in aging cells, making it one of the most biologically advanced geroprotective peptides.

Schemat działania Cortagenu

Figure 1. Effect of Cortagen peptide on gene expression in the heart, comparing hybridization of control and heart probes using Cortagen to the NIA 15K cDNA microarray (fragment). As shown in the above study (circles), Cortagen peptide gave rise to clones with altered expression (Dst, dystonin; Ampd3, H-type AMP deaminase), demonstrating its potential myocardial protective effect compared to the control.

CORTAGEN and oxidative stress and inflammation

The peptide exhibits potent antioxidant properties, reducing lipid peroxidation products and increasing the activity of protective enzymes such as SOD and catalase. It helps restore balance between pro- and anti-inflammatory pathways in the nervous system, supporting natural cellular homeostasis.

CORTAGEN and cognitive functions and mood

In animal models and clinical observations, CORTAGEN improved memory, concentration, and cognitive abilities, and also demonstrated mood-stabilizing effects. Its neurotrophic effect promotes better information processing and increases the nervous system's resistance to emotional overload and stress.

 

Feature Biological effect
Regulation of gene expression Regeneration and "rejuvenation" of nerve cells
Neurogenesis and synaptogenesis Improving cognitive functions and memory
Antioxidant effect Protection of neurons against oxidative stress
Chromatin stabilization Slowing down the cellular aging processes
Nerve conduction support Better communication between neurons and resistance to stress

 

This product is intended and labeled as a research reagent only. This label allows research chemicals to be used exclusively for in vitro research and laboratory experiments. All product information available on this website is for educational purposes only. Introducing this product into the bodies of humans or animals is strictly prohibited by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and must not be mislabeled, misbranded, misused, or mislabeled as a drug, food, or cosmetic.

Bibliography
  1. W.Adriani , O.Granstrem , E.Romano , O.Granstrem , S.Koroleva, G.Laviola, Modulatory Effects of Cortexin and Cortagen on Locomotor Activity and Anxiety-Related Behavior in Mice. The Open Neuropsychopharmacology Journal; 2011, 2: 22-29. doi: 10.2174/1876523800902010022
  2. T.Fedorova, N.Boldyrev, A.Khavinson, Neuroprotective properties of the synthetic peptide Cortagen. Bulletin of Experimental Biology and Medicine. 2001. DOI: 10.1023/A:1014445014563
  3. V.Khavinson, E.Grigoriev, I.Ryzhak, Effects of the peptide Cortagen on the regeneration of nerve tissue. Neuroscience and Behavioral Physiology. 2003. DOI: 10.1023/A:1024404701418
  4. V.Khavinson, I.Ryzhak, E.Grigoriev, Cortagen effects on memory and learning in neurodegenerative disorders. Journal of Peptide Science. 2011. DOI: 10.1002/psc.1362
  5. V.Sergey, V.Khavinson, V.Anisimov, Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. 2004; NeuroendocrinologyLetters