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BPC-157 5mg + BAC Water – regenerative peptide for injuries and tissue healing.
WHAT IS BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide, a fragment of a natural protein found in human gastric juice.
Its unique 15-amino acid structure was designed to maintain stability and biological activity in the harsh conditions of the gastric environment.
BPC-157 demonstrates high effectiveness in regenerative processes, supporting the regeneration of soft tissue, tendons, muscles, and bones. Laboratory studies have confirmed its effect on angiogenesis, collagen synthesis, and regulation of the body's inflammatory response.
BPC-157 HAS PROTECTIVE AND REGENERATIVE EFFECTS THANKS TO:
- Stimulation of angiogenesis – stimulates the production of vascular endothelial growth factor (VEGF), improving microcirculation and accelerating the repair of damaged tissues.
- Increased collagen synthesis – supports the regenerative processes of skin, tendons, and mucous membranes.
- Anti-inflammatory action – reduces oxidative stress and modulates the activity of proinflammatory cytokines (TNF-α, IL-6).
- Protection of the vascular endothelium – stabilizes cell membranes and limits capillary degradation.
- Regulation of cellular homeostasis – supports the balance between cell proliferation and apoptosis, accelerating the regeneration process.
💡Effect: faster wound healing, regeneration after injuries and procedures, and improved function of the digestive and musculoskeletal organs.
BPC-157 PEPTIDE STRUCTURE
- Amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Summary formula: C₆₂H₉₈N₁₆O₂₂
- Molecular weight: 1419,56 g/mol
- Form: lyophilisate (white/cream), soluble in demineralized water
BIOLOGICAL RESEARCH AND EFFECTS
BPC-157 and the wound healing process
BPC-157 demonstrates the ability to rapidly generate new tissue and stimulate collagen.
It supports angiogenesis by increasing VEGF expression, which improves blood flow and nutrient transport.
In in vivo models, a significant reduction in healing time has been observed for wounds, burns, and skin lesions.
BPC-157 and tendon and muscle regeneration
The compound stimulates the activity of fibroblasts, responsible for collagen production and connective tissue remodeling.
Studies have shown that BPC-157 increases blood flow to the site of injury and improves the elasticity and mechanical resistance of tendons.
Figure 1. The study was conducted in laboratory conditions over 7 days. The study compared damaged tendon cells in the control group, untreated, with the test group (BPC-157 at concentrations of 1 µg/ml and 2 µg/ml). The findings clearly show an increased number of fibroblasts in the group treated with the BPC-157 peptide at both concentrations, demonstrating the peptide's positive effect on damaged tendons.
BPC-157 and the digestive system
The compound exhibits strong cytoprotective effects on the gastric and intestinal mucosa.
It accelerates the regeneration of damaged epithelium, reduces inflammation, and limits the secretion of hydrochloric acid.
BPC-157 and the skeletal system
The peptide supports osteogenesis by stimulating osteoblast activity and increasing the synthesis of type I collagen.
In fracture models, a shortened bone healing time and improved mechanical strength were observed.
| Feature | Biological effect |
|---|---|
| Stimulation of angiogenesis (VEGF) | Accelerated wound healing, improved blood supply and tissue nutrition |
| Increasing collagen synthesis | Regeneration of skin, tendons, muscles and mucous membranes |
| Activation of fibroblasts and osteoblasts | Faster reconstruction of connective and bone tissues |
| Anti-inflammatory effect | Reduction of pro-inflammatory cytokines (TNF-α, IL-6) and oxidative stress |
| Protection of the vascular endothelium | Stabilization of capillaries, improvement of microcirculation |
| Regulation of cellular homeostasis | Supporting the balance between cell proliferation and regeneration |
| Cytoprotective effect on the digestive system | Regeneration of the gastric and intestinal mucosa, protection against damage |
| Increased blood flow to the site of injury | Improving the transport of oxygen and nutrients to tissues |
| Antioxidant effect | Limiting free radicals and supporting natural defense mechanisms |
| Accelerating recovery processes after injuries and surgeries | Shorter recovery time and more complete healing |
Bibliography
- L.He, D. Feng, H.Guo, Y.Zhou, Z. Li, K. Zhang, W. Zhang, S. Wang, Z. Wang, Q. Hao, C. Zhang, Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. 2022; 13: 1026182. 10.3389/fphar.2022.1026182
- S.Seiwerth, M. Milavic, J. Vukojevic, S. Gojkovic, I. Krezic, L. Batelja-Vuletic, K. Pavlov, A. Petrovic, S. Sikiric, H. Vranes, A. Blagaic, P.Sikiric, Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. 2021; 12: 627533. 10.3389/fphar.2021.627533
- D.Perovic, D. Kolenc, V. Bilic, N. Somun, D. Drmic, E. Elabjer, G. Buljat, S. Seiwerth, P. Sikiric, Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. 2019; 14: 199. 10.1186/s13018-019-1242-6
- M.Staresinic, M Japjec, H. Vranes, A. Prtoric, H. Zizek, Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. 2022; 10(12): 3221. 10.3390/biomedicines10123221
- S.Strbe, S. Gojkovic, I. Krezic, H. Zizek, H. Vranes,I. Barisic, D. Strinic, Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157. 2021 Nov; 9(11): 1506. 10.3390/biomedicines9111506
- C.Chang, W. Tsai, M. Lin, Y. Hsu, J. Pang, The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. 201; 110(3):774-80. doi:10.1152/japplphysiol.00945.2010.