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TECHNOLOGY AND RESEARCH
Research, patents and technology
A new generation of peptides: NL-PEPTIDES™ + NL-PEPTIDES-DELIVERY™. Synthesized in Europe. Tested in accredited laboratories in Poland, Germany, and Switzerland. The result: greater stability, bioavailability, and predictable action.
Purity, stability, and precision are the foundation of everything we create. Every SYNTHAGEN product is based on patented NL-PEPTIDES™ and NL-DELIVERY™ technologies, which guarantee maximum bioavailability and effectiveness.
We operate a transparent, rigorous research process, ensuring you receive a product of proven laboratory quality. This isn't an industry standard—it's the SYNTHAGEN standard.
scientific approach
There is science behind every product
Our patent-protected NL-PEPTIDES™ and NL-DELIVERY™ technologies are the result of years of research into peptide stability and absorption. These technologies enable our products to achieve higher biological efficacy than conventional formulas.
Every batch of SYNTHAGEN products undergoes independent testing in accredited laboratories in Poland, Germany, and Switzerland. We examine purity, concentration, and compositional consistency to ensure that each peptide meets the highest safety and quality standards.
Our peptides are synthesized in Europe under strictly controlled laboratory conditions, using certified raw materials and methods. This is where the precisely designed structure of each peptide is created, ensuring its stability, durability, and full biological activity.
NL-PEPTIDES
What are NL-PEPTIDES?
NL-PEPTIDES™ are innovative analogues of classic peptides—designed to maintain their biological activity despite the effects of stomach acids, digestive enzymes, and high temperatures.
Thanks to precise modifications of the chemical structure (acetylation and amidation of the amino acid chain ends), we have obtained peptides with stability comparable to the body's natural proteins.
Their amino acid profile remains intact, meaning they retain their original shape and full activity even after passing through the digestive system.
As a result, NL-PEPTIDES™ are effective not only after injection but also when taken orally, something previously impossible with traditional peptides.
PRODUCTS
What is NL-PEPTIDES-DELIVERY™?
Patented double-capsule technology for effective peptide delivery. NL-PEPTIDES-DELIVERY™ is our patented oral peptide delivery system.
It was developed to address two of the biggest challenges faced by peptides: degradation in the stomach and poor bioavailability in the intestine. The outer capsule is coated with a special acid-resistant coating, allowing it to bypass the stomach and reach the small intestine intact.
Inside, there's a second capsule—a microcapsule containing the active peptide, a protease inhibitor (a substance that blocks enzymes that break down proteins), and an absorption enhancer that facilitates the compound's penetration through the intestinal barrier. This technology ensures the peptide is fully protected until absorbed and can act with full biological effectiveness.
In vitro and in vivo study results clearly confirm that NL-PEPTIDES-DELIVERY™ increases plasma peptide concentrations several times over conventional capsule forms.
EFFECT
A new standard in peptide technology
By combining two patented technologies – NL-PEPTIDES™ and NL-PEPTIDES-DELIVERY™ – we have created a system that solves three fundamental problems:
- Stability – peptides resistant to external factors and digestive enzymes.
- Protection – no degradation in the stomach thanks to an acid-resistant capsule.
- Bioavailability – full absorption and presence in the bloodstream.
This is not just a technological innovation. It is a breakthrough that enables the effective and safe use of peptides in a convenient oral form, without losing their natural biological properties.
EP22156902
European patent covering the technology for the synthesis and stabilization of peptide analogues within the NL-PEPTIDES™ platform and the NL-PEPTIDES-DELIVERY™ oral delivery system.
DownloadAnalytical research
Report on comprehensive analyses of purity, stability and biological activity of NL peptides, performed in accredited laboratories in Poland and Germany.
DownloadProduct composition testing
The document contains detailed chemical composition test results confirming the molecular consistency and pharmaceutical quality of Synthagen Labs peptides.
DownloadCharacterization and evaluation of the functionality of the NL-BPC-157 product
Analysis of the biological properties of the NL-BPC-157 peptide, including tests of stability, bioavailability and regenerative effectiveness at the cellular level.
DownloadCharacterization and evaluation of the functionality of the NL-Epithalon product
A document describing the effect of NL-Epithalon on telomerase expression, cellular regeneration processes and slowing down the mechanisms of biological aging.
DownloadCharacterization and evaluation of the functionality of the NL-GHK-CU product
Evaluation of the action of the peptide-copper complex in the context of skin regeneration, collagen synthesis and antioxidant protection of cells.
DownloadCharacterization and evaluation of the functionality of the NL-Cortagen product
Report on the neuroprotective properties of NL-Cortagen – nerve cell regeneration, DNA stabilization and regulation of gene expression.
DownloadCharacterization and evaluation of the functionality of the NL-Selank product
Document confirming the anti-anxiety, mood-stabilizing and cognitive-supporting effects of the NL-Selank peptide.
DownloadCharacteristics and evaluation of the functionality of the NL-Semax product
Research on the effect of NL-Semax on concentration, memory, neurogenesis and protection of nerve cells against oxidative stress.
DownloadChromatography and MS spectrometry of basic peptides
Results of chromatographic and spectrometric analyses confirming the purity, molecular weight and structural integrity of the base peptides.
DownloadChromatography and MS spectrometry of NL-peptides
Detailed structural and molecular analysis of peptides using NL-PEPTIDES™ technology, confirming their compliance with the reference model and pharmaceutical stability.
DownloadSynthagen
SynthagenLabs Research and Patents
All of our technological solutions and peptide formulas are based on years of research and development, confirmed by patents and laboratory analysis results.
Every Synthagen Labs product undergoes a complete quality verification process – from synthetic purity and structural stability to bioavailability and safety assessment.
Our patent applications cover the NL-PEPTIDES™ peptide analog synthesis technology and the NL-PEPTIDES-DELIVERY™ oral delivery system, representing a new standard in pharmaceutical peptide biotechnology.
NL-PEPTIDES
Patented peptides
The tables below compare NL-peptides with conventional peptides. Comparative studies were conducted in an environment resembling the gastrointestinal tract, as well as during storage of the peptides themselves and in their reconstituted form (vials).
NL-PEPTIDES - Your new, better, patented peptides.
The tables below compare NL-peptides with conventional peptides. Comparative studies were conducted in an environment resembling the gastrointestinal tract, during storage, and in dissolved form (vials).
Conclusion: NL-peptides are much more stable than conventional peptides, making them suitable for use in capsules and oral pharmaceutical formulations.
Analyses of basic peptides and NL-Peptides in an environment mimicking the pH3 stomach environment.
Analyses of basic peptides and NL-Peptides in an environment mimicking the stomach environment of pH5.5.
Stability of peptide lyophilisates during storage.
Lyophilized samples were stored in sealed vials for 365 days at 35°C and standard humidity. Analyses were performed by opening each vial at monthly intervals.
Stability of aqueous solutions during storage.
Structural stability was assessed by analyzing peptide solutions prepared as follows: Peptide solutions were prepared at a concentration of approximately 1 mg/ml in demineralized water (pH approximately 5.6). These solutions were stored under controlled conditions at 40°C and 55% humidity, and assays were performed at regular intervals.
NL-PEPTIDES-DELIVERY TM - Your new, patented double capsule technology.
Results of tests for NL-peptide concentrations in blood
The first three example graphs show peptide peaks from properly prepared blood samples, analyzed over a 120-minute period. For NL-GHK-CU, NL-EPITHALON, and NL-BPC-157, administered using our patented NL-PEPTIDES-DELIVERY™ delivery technology, and for the standard peptides GHK-CU, EPITHALON, and ARG-BPC administered in standard capsules. The next three graphs show the distribution of peptide concentrations in the tested blood over a time period of 30-360 minutes, converted to pg/ml.
Conclusion: Our dual-encapsulation technology makes oral peptide administration possible. The graphs below demonstrate how our technology works.
Source: EP22156902 oraz P22156902
BIOTECHNOLOGICAL RESEARCH - how do our products work?
Source: Characterization and evaluation of product functionality NL-GHK-CU, NL-EPITHALON, NL-BPC-157, NL-CORTAGEN, NL- SEMAX, NL-SELANK.
For example, we have conducted studies such as: assessing the impact of in vitro digestion on active ingredients in products, including assessing the bioavailability of active ingredients across the gut-blood barrier. We also assessed the rate of release of active ingredients (peptides) from products in the gastrointestinal tract, as well as determining dosages, and much more.
Conclusion: Our NL-peptides penetrate the intestine intact and easily cross the gut-blood barrier. Simply put, they work, and their amino acid profile remains unchanged.
PRODUCT COMPOSITION RESEARCH - WHAT AM I BUYING?
Source: Product composition research.
The tested samples were applied in 15 µl amounts to a Thermo Scientific BioBasic 8 column. During the linear gradient analysis, peaks of the desired substances appeared in H2O and acetonitrile solutions with 0.1% trifluoroacetic acid added. Their concentrations, after comparison to the reference chromatogram, are presented in the tables. The measurement error is +/- 0.5 mcg.
Conclusion: Our products contain the composition consistent with the declared content.
Source: ANALYTICAL Research
ANALYTICAL TESTS - AM I BUYING SAFE PRODUCTS?
The following tests were performed: the presence of coronobacter, microbiology, alkaloids, the presence of heavy metals, the presence of ethyl oxide.
Conclusion: Our products are safe.
